Greg Calligaro Definition and classification of pulmonary hypertension

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Haemodynamic definition of pulmonaryhypertensionPHMean PAP ≥25 mm HgPre-capPHPost-capPHMean PAP ≥25 mm Hg plusPCWP/LVEDP ≤15 mm HgMean PAP ≥25 mm Hg plusPCWP/LVEDP >15 mm HgBadesch D et al. J Am Coll Cardiol. 2009;54:S55-S66.McLaughlin VV et al. J Am Coll Cardiol. 2009;53:1573-1619.Badesch et al. JACC, 2009.Halpern SD, et. al. Chest, 2009.
PH: importance of PCWP• Identifies patients with PH due to leftheart disease• An accurate PCWP can be difficultto obtain in patients with PH andenlarged pulmonary arteries• Patients with PCWP ≥ 15mmHgshould have their LVEDP directlymeasured by left heartcatheterisation (LHC)• A recent retrospective study ofsubjects undergoing both RHC andLHC showed that 5% of patientswith elevated PCWP had normalLVEDPHalpern SD, et. al. Chest, 2009.
Page 1 and 2: Definition andclassification ofpulm
Page 3: Haemodynamic definition of pulmonar
Page 9 and 10: WHO Group 1 PAH1. PAH•Idiopathic
Page 11 and 12: Group 1: PAH associated with HIV in
Page 13 and 14: PAH related to portal hypertension
Page 15 and 16: PAH related to schistosomiasis• P
Page 18 and 19: Group 1’: PVOD and PCH• Ground
Page 20 and 21: Changes to WHO Group 1 (Dana Point
Page 22 and 23: Group 2: Left heart diseaseNormalTi
Page 24 and 25: Group 3: Secondary to lung disease/
Page 26 and 27: Group 4: CTEPH• Most pulmonary em
Page 28 and 29: Pathophysiology• “Two compartme
Page 30 and 31: Group 4: CTEPH
Page 32 and 33: Group 5: Unclear or multifactorial
Page 34 and 35: Summary• Pulmonary hypertension i

Greg Calligaro Definition and classification of pulmonary hypertension

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