endotoxins adsorption - CRRT Online

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oXiris: Action ModeEndotoxin <strong>adsorption</strong>Endotoxin:‣ large MW molecule (100 000 to 5M)‣ major component of gram – bacteria‣ chemical composition: polysaccharide, carbohydrate and lipid A (LPS)Lipid A (active part of endotoxin)OOP-OOIonic bondingwith free aminegroups of PEI** S. Morimoto et al, Polymer journal, vol.27, 8, 1995, 831S. Mitzner et al, Artificial organs, 17 (9), 1993, 775
Endotoxins <strong>adsorption</strong> – in vitroHonore PM,Clark W et al.,Proceeding of the 10 WFCCM,Florence 2009
Page 1: Exp Studies for HVHF,HPHF&Hybrid Th
Page 5 and 6: III) Should We Target SIRS,Immunopa
Page 9 and 10: Solute Classes by MolecularWeightDa
Page 11 and 12: Recent HPHF Studies in Sepsis:mL /
Page 13 and 14: VI)Hybrid Systems Recent HPHF Studi
Page 15 and 16: Hybrid Systems : The Possible Answe
Page 17 and 18: Hybrid Systems : PMX Cartridges(EUP
Page 19 and 20: AN69 ST* and Heparin AdsorptionHep.
Page 21 and 22: -New HyperAdsorptive Membrane(oXiri
Page 23: oXiris: Action ModeLow molecular we
Page 27 and 28: Β2M Adsorption IsothermsPorous AN6
Page 29 and 30: LAL response EU/mLEndotoxin Removal
Page 31 and 32: RIFLE CriteriaGFR CriteriaUrine Out
Page 33 and 34: VIII) The Future: Ongoing PRT’s:
Page 35 and 36: =75Patients (%)Patients (%)DoReMi D

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