Toxicological Evaluation and Limit Values for ... - MiljÃ¸styrelsen

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Table 2. Oral LD 50 -values for nonylphenol ethoxylates with variousethylene oxide (EO) chain lengths (compiled from CIR 1983 (C) andTalmage 1994 (T))Numberof EOunitsLD 50(mg/kg)Species(Reference; quoted from)2 3550 rat (Consumer Product Testing Co., 1978; C)4 5000 rat (Schick, 1967; T)4 4290 rat (Schick, 1967; T)4 4800 rat (Monsanto Chemical Company, 1975; T)4 7400 rat (M.B. Research Labs, 1978; C)4 4300 rat (Mellon Institute of Industrial Research, 1963; C)4 >5000 rat (Texaco Chemical Company, 1991; T)4 5000 guinea pig (Schick, 1967; T)5 3250 rat (Monsanto Chemical Company, 1975; T)6 1980 rat (Consumer Product Testing Co., 1978; C)7 3600 rat (Monsanto Chemical Company, 1975; T)7 3670 rat (Schick, 1967; T)7 3670 rat (Mellon Institute of Industrial Research, 1963; C)8-9 3000 rat (Schick, 1967; T)8-9 2000 guinea pig (Schick, 1967; T)9 2600 rat (Smyth & Calandra, 1969)9 2600 rat (Schick, 1967; T)9 5600 rat (Monsanto Chemical Company, 1975; T)9 1410-3000 rat (Mellon Institute of Industrial Research, 1963; C)9 620 rabbit (Mellon Institute of Industrial Research, 1963; C)9 4400 rabbit (Industrial Toxicology Labs., 1960; C)9 840 guinea pig (Mellon Institute of Industrial Research, 1963; C)9 2000, guinea pig (Industrial Toxicology Labs., 1960; C)9 4290 mouse (Mellon Institute of Industrial Research, 1963; C)9.5 3300 rat (Texaco Chemical Company, 1991; T)9-10 1600 rat (Olson et al., 1962; T)10 1300 rat (Mellon Institute of Industrial Research, 1963; C)10.3 4800 rat (Monsanto Chemical Company, 1975; T)10.5 2500 rat (Schick, 1967; T)12 2170 rat (Monsanto Chemical Company, 1975; T)12 3900 rat (Texaco Chemical Company, 1991; T)12 5100 rat (Consumer Product Testing Co., 1978; C)12 871-1050 rabbit (Monsanto Chemical Company, 1959; T)13 3730 rat (Mellon Institute of Industrial Research, 1963; C)13 5600 rat (Monsanto Chemical Company, 1975; T)13.5 2500 rat (Schick, 1967; T)15 2500 rat (Industrial Biology Research and Testing Labs., 1960; C)15 4000 rat (Schick, 1967; T)20 15900 rat (Schick, 1967; T)20 >16000 rat (Schick, 1967; T)Dermal contactFor NP, a dermal LD 50 -value of 2031 mg/kg in rabbits has been reported(EU-RAR 1998)For NPE, the acute dermal toxicity for a number of NPEs with a varyingnumber of ethoxylene oxide units has been determined in rabbits (Table3).14
Table 3. Dermal LD 50 -values in rabbits for nonylphenol ethoxylates withvarious ethylene oxide (EO) chain lengths (compiled from CIR 1983 (C)and Talmage 1994 (T))Numberof EOunitsLD 50(mg/kg)Reference; quoted from4 >2000 Monsanto Chemical Company, 1975; T4 2500 Mellon Institute of Industrial Research, 1963; C4 >3000 Texaco Chemical Company, 1992; T5 >3160 Monsanto Chemical Company, 1975; T7 >3160 Monsanto Chemical Company, 1975; T7 1800 Mellon Institute of Industrial Research, 1963; C9 >5010 Monsanto Chemical Company, 1975; T9 4400 Consumer Product Testing Co., 1978; C9 2830 Mellon Institute of Industrial Research, 1963; C9.5 >3000 Texaco Chemical Company, 1992; T10 >2000 Monsanto Chemical Company, 1975; T10 2000 Mellon Institute of Industrial Research, 1963; C12 >10000 Monsanto Chemical Company, 1975; T12 >3000 Texaco Chemical Company, 1992; T13 >7940 Monsanto Chemical Company, 1975; T13 3970 Mellon Institute of Industrial Research, 1963; C40 >10000 Monsanto Chemical Company, 1975; T40 >5000 Mellon Institute of Industrial Research, 1963; CIrritationNP is corrosive on contact with skin and is a severe eye irritant. Exposureto the saturated vapour may lead to mild sensory irritation of the respiratorytract (EU-RAR 1998).4.2 Long term toxicityInhalationNo data have been found.Oral administrationNP 28-day studyIn a 28-day study (quoted in IUCLID 1996) performed according toOECD guideline 407 (in 1981), doses of 0, 25, 100 or 400 mg/kg/day ofNP were administered to Sprague-Dawley rats in the diet. At the highestdose level, body weight, food consumption, and food utilisation was statisticallysignificantly reduced in both sexes. Also at the highest doselevel, for male animals only, relative kidney, liver and testes weightswere statistically significantly increased (by 20%), blood urea and cholesterollevels were statistically significantly increased, and glucose wasstatistically significantly reduced. Histopathological examination revealedhyaline droplet accumulation in the renal proximal tubules, and aminor vacuolation in the periportal hepatocytes. Females did not showthese effects. In the EU-RAR (1998), the NOAEL is considered to be 10015
Page 1 and 2: Environmental Project No. 512 2000M
Page 3 and 4: 1 General description1.1 IdentityNo
Page 5 and 6: with varying average lengths of the
Page 7 and 8: 1.4 Environmental occurrenceNP and
Page 9 and 10: 2 Toxicokinetics2.1 Absorption, dis
Page 11 and 12: 3 Human toxicity3.1 Short term toxi
Page 13: 9 concentrated vapour atambient tem
Page 17 and 18: Table 4a Number of animals with his
Page 19 and 20: with 40 ethylene oxide units, no ef
Page 21 and 22: *) In the original report, dose was
Page 23 and 24: Table 7 Results of studies in dogs
Page 25 and 26: Dermal contactNo data have been fou
Page 27 and 28: generation reproduction toxicity st
Page 30 and 31: 5 Regulations, limit valuesAmbient
Page 32 and 33: units is low, as LD 50 values varyi
Page 34 and 35: 7 EvaluationA study in humans invol
Page 36 and 37: mg/kg/day were found in rats. In do
Page 38 and 39: = 25 mg/kg soilNPEBased on the TDI
Page 40 and 41: is set at the limit value. A C-valu
Page 42 and 43: Odum J, Lefevre PA, Tittensor S, Pa

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