Toxicological Evaluation and Limit Values for ... - MiljÃ¸styrelsen

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The Danish Environmental Protection Agency will, when opportunityoffers, publish reports and contributions relating to environmental researchand development projects financed via the Danish EPA.Please note that publication does not signify that the contents of the reportsnecessarily reflect the views of the Danish EPA.The reports are, however, published because the Danish EPA finds that thestudies represent a valuable contribution to the debate on environmentalpolicy in Denmark.
1 General description1.1 IdentityNonylphenol (NP) is the commercially most important member of thegroup of alkyl phenols. The term “nonylphenol” represents a large numberof isomeric compounds, varying in the point of attachment of thenonyl group to the phenol molecule, and in the degree of branching in thenonyl moiety. Commercially produced nonylphenols are predominantly4-nonylphenol (para-nonylphenol) with a varied and undefined degree ofbranching in the alkyl group, while very little straight chain nonylphenolis present (EU-RAR 1998).Similarly, nonylphenol ethoxylate (NPE) is the most important alkylphenolethoxylate. NPE accounts for approximately 85% of alkylphenol ethoxylateproduction (Anonymous 1997). An NPE is composed of a nonylchain, usually branched, attached to a phenol ring (hydrophobe moiety)which is combined, via an ether linkage, with one or more ethylene oxideor polyoxyethylene units (hydrophile moiety).A particular NPE is identified by the length of the polyoxyethylene chain(average number of ethylene oxide units, abbreviated EO). NPEs of aparticular average ethylene oxide chain length, produced by differentmanufacturers, may differ in ranges of ethylene oxide chain lengths.Molecular formula:Structural formula:NP: C 15 H 24 ONPE: C 15 H 24 O(C 2 H 4 O) nC 9 H 19OHNonylphenolC 9 H 19 O [CH 2 CH 2 O] n-1 CH 2 CH 2 OHNonylphenol ethoxylate, generalised formulan = number of ethyle oxide unitsMolecular weight: NP: 220NPE: 220 + n x 44where n is the number of ethoxylene units (n canvary from 1-100).CAS-no.: Nonyl phenol: 84852-15-33
Page 1: Environmental Project No. 512 2000M
Page 5 and 6: with varying average lengths of the
Page 7 and 8: 1.4 Environmental occurrenceNP and
Page 9 and 10: 2 Toxicokinetics2.1 Absorption, dis
Page 11 and 12: 3 Human toxicity3.1 Short term toxi
Page 13 and 14: 9 concentrated vapour atambient tem
Page 15 and 16: Table 3. Dermal LD 50 -values in ra
Page 17 and 18: Table 4a Number of animals with his
Page 19 and 20: with 40 ethylene oxide units, no ef
Page 21 and 22: *) In the original report, dose was
Page 23 and 24: Table 7 Results of studies in dogs
Page 25 and 26: Dermal contactNo data have been fou
Page 27 and 28: generation reproduction toxicity st
Page 30 and 31: 5 Regulations, limit valuesAmbient
Page 32 and 33: units is low, as LD 50 values varyi
Page 34 and 35: 7 EvaluationA study in humans invol
Page 36 and 37: mg/kg/day were found in rats. In do
Page 38 and 39: = 25 mg/kg soilNPEBased on the TDI
Page 40 and 41: is set at the limit value. A C-valu
Page 42 and 43: Odum J, Lefevre PA, Tittensor S, Pa

Toxicological Evaluation and Limit Values for ... - MiljÃ¸styrelsen

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