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NIH Clinical Pharmacology 3-25-10Non<strong>clinical</strong> Drug DevelopmentIn Vitro Pharmacology Models• In vitro studies performed in cell lines or cellfreesystems– Often form the basis for screening andoptimization during discovery• Oncology uses human tumor cell lines forevaluation of:– Mechanism of action– Evaluation of potency and selectivity– Early indication selection– <strong>Pre</strong>dictive biomarker discovery10
NIH Clinical Pharmacology 3-25-10In Vitro Cell Line AnalysesCisplatinCarboplatinCellLinesRelative Potency (GI 50 )11
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