Pre-clinical drug development_1slide
Pre-clinical drug development_1slide
Pre-clinical drug development_1slide
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NIH Clinical Pharmacology 3-25-10Characteristics of MolecularlyTargeted Therapies (adapted from Paoletti 2005)Characteristic Cytotoxic Agents Targeted AgentsDiscoveryCell based, empiricalReceptor basedscreen, rationaleMechanism Often unknown Basis for screeningPharmacologicalEffectCytotoxicCytostaticSpecificity Non-selective SelectiveDose and scheduleDevelopmentStrategyPulsed, cyclical at MTDBiomarkers for decisionmaking is rareContinuous, attolerable doseBiomarkers forPD/MofA and patientselection49
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