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NIH Clinical Pharmacology 3-25-10A Blueprint for a RestructuredDrug Development OrganizationDiscoveryEarlyDevelopmentLateDevelopmentEarly <strong>clinical</strong><strong>development</strong>NMEPh1/2aPOCPhase2bPhase3• How to make better decisions at POC?• How to improve the probability of success(pTS) in Phase 2b and 3?PWIP x pTS x VC x CT-- Modified from Paul et al, Nature Rev Drug Discov 201047
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