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NIH Clinical Pharmacology 3-25-10In Vivo Efficacy Models in Cancer• Spontaneous tumors– Idiopathic– Carcinogen-induced– Transgenic/gene knockout animals: p53, RB, etc• Transplanted tumors– Syngeneic animal tumors: Lewis lung, S180sarcoma, B16 melanoma murine tumors– Human tumors growing in vivo in implantablehollow fibers17
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