12.07.2015 Views

Sarah Larney, Bradley Mathers and Kate Dolan Illicit drug treatment ...

Sarah Larney, Bradley Mathers and Kate Dolan Illicit drug treatment ...

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2. DETOXIFICATIONDetoxification is the management of withdrawal symptoms associated with the cessationof a <strong>drug</strong> of dependence. While not a <strong>treatment</strong> for <strong>drug</strong> dependence in itself, assisting a<strong>drug</strong> dependent person to detoxify safely <strong>and</strong> with a minimum of discomfort or dangerto their health may lead to further opportunities for clinicians to provide harm reductioninterventions or <strong>drug</strong> <strong>treatment</strong> services.There is a paucity of literature detailing or evaluating detoxification protocols in eithercommunity or prison settings. However, detoxification in prison need not differmarkedly from that provided in the community. Withdrawal can be managed in anumber of ways, depending on the <strong>drug</strong> or <strong>drug</strong>s of dependence. Medical interventionmay assist the detoxification process, particularly in the case of opiate dependence.Alternatively, detoxification can be managed non-medically, through the provision ofpsychological support <strong>and</strong> care.2.1 Opiate detoxificationOpiate detoxification is rarely life-threatening <strong>and</strong> clinical management is uncomplicated.Management of opiate withdrawal typically involves the use of alpha2-adrenergic agonists(e.g. clonidine, lofexidine), opioid agonists (e.g. methadone, buprenorphine) <strong>and</strong>/orsymptomatic <strong>treatment</strong>.2.1.1 Alpha2-adrenergic agonistsOne of the neurological mechanisms underlying opioid withdrawal is noradrenergichyperactivity. Alpha2-adrenergic agonists, such as clonidine <strong>and</strong> lofexidine, relieve opiatewithdrawal symptoms by moderating this activity (Gowing, Farrell, & White, 2004).Several community-based studies have examined the use of clonidine <strong>and</strong> lofexidine. Areview of studies found that withdrawal symptoms are similar whether adrenergicagonists or methadone is utilised. Treatment retention is worse compared to methadone-10

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