Clinical Pearls and Myths in Vasculitis

Polyarteritis Nodosa: PearlMononeuritis multiplex, defined as a peripheral neuropathy in whichnamed nerves are injured or infarcted one at a time, is one of the great"eureka" signs in medicine, because it has such a limited differentialdiagnosisPAN, MPA, Wegener 's granulomatosis (WG), Churg-Strauss syndrome (CSS), and cryoglobulinemia are the forms of systemicvasculitis most commonly associated with mononeuritis multiplexRA, Sjogren’s, SLE, can also cause mononeuritis but often after monthsto years while it typically occurs early in primary vasculitidesHellmann D, Liang T, Petri M, et al: Mononeuritis multiplex: The yield of the evaluation for occult rheumatic diseases. Medicine67:145-153, 1988