Clinical Pearls and Myths in Vasculitis

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WG’s: MythThis point has also been emphasized in patients with MPAAmong 107 patients with MPA and GN in one study, 23 (21%) requireddialysis at presentation. Of the 17 patients who received aggressivetreatment, 9 no longer required dialysis after 3 monthsCYC should be dosed for renal failure to avoid major drug toxicity,reducing the dose by 50% for those on dialysis (i.e., 1 mg/kg/d ratherthan 2 mg/kg/d)MTX should not be used in patients with a serumcreatinine level greater than 200 umol/LNachman P, Hogan S, Falk R, et a1 Treatment response and relapse in antineutrophil cytoplasmicautoantibody-associated microscopic polyangiitis and glomerulonephritis.J Am SOC Nephrol733-39,1996
WG’s: MythDose reductions in the elderly are also advisableFinally, if renal function does not improve within severalmonths, the patient is likely to require some form of renalreplacement therapy permanentlyIn such cases, the choice of therapy should be predicatednot on achieving a return of renal function but rather onthe severity of nonrenal disease manifestations.MekhailT, Hoffman G: Long-term outcome of Wegener’s granulomatosis in patients with renal diseaserequiring dialysis. J Rheumatol 27:1237-1240, 2000
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Polyarteritis Nodosa: PearlMononeur
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Giant Cell ArteritisGiant Cell Arte
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Giant Cell ArteritisNew Unexplained
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Giant Cell ArteritisA Rising Erythr
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Giant Cell Arteritis: MythSome pati
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Page 60 and 61: Polymyalgia Rheumatica:MythMost pol
Page 62 and 63: Polymyalgia RheumaticaIf a Patient
Page 64 and 65: Polymyalgia Rheumatica:PearlReview
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Page 100 and 101: WG’s: MythAlthough laser surgery
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Clinical Pearls and Myths in Vasculitis

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