Role of Mirena in HRT - Nick Panay

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Aerodiol, , a unique pharmacokinetic profile• Aerodiol a new concept in HRT, pulsed oestrogen therapy.• This pulsed effect ensures effective oestrogenexposure in the target tissues• Aerodiol is characterised by an originalpharmacokinetic profile differing from the somewhatflatter, more sustained kinetic profiles seen withtransdermal and oral therapy.Devissaguet et al. (1999) Eur J Drug Metabol 24, 256-271
Aerodiol: “pulsed” pharmacokinetic profilePanay et al Maturitas 2001pg/mL140012001000800600AERODIOL ® 300µgOestradiolOestronePlasma oestradiol : rapidly distributed40020010%Untreated postmenopausal level00 2 4 6 8 12 24 (hours)
Page 1 and 2: HRTNew delivery systemsImperial Col
Page 3 and 4: New delivery systems for HRT• Pha
Page 5 and 6: New delivery systems for HRT• Des
Page 7 and 8: Routes of AdministrationAdvantagesO
Page 9 and 10: HRTVaginal PreparationsP• Product
Page 11 and 12: HRT Delivery SystemsIntranasal
Page 13: Aerodiol - intranasal HRT• 17 Bet
Page 17 and 18: Tissue response to pulsed oestrogen
Page 20 and 21: Schematic representations of kineti
Page 22 and 23: ANGELIQ ®Comparison of Drospirenon
Page 24 and 25: Red Clover
Page 26 and 27: HRT: Maximising EfficacyMinimising
Page 28 and 29: Selectiveelective oEstrogenReceptor
Page 30 and 31: Role of ERα and ERβ in Body Organ
Page 32: HRT: Maximising EfficacyMinimising
Page 35 and 36: Specific binding affinities:nuclear
Page 37 and 38: HRT Delivery SystemsSkin - patches
Page 39: HRT delivery systems - skinTransder
Page 42 and 43: HRT delivery systems - skin• Matr
Page 44: HRT Delivery SystemsSkin - creams/g
Page 48 and 49: HRT Delivery SystemsSubcutaneous im
Page 50 and 51: HRT Delivery SystemsUterine systems
Page 52 and 53: Mirena - mechanism of action
Page 54 and 55: Mirena - endometrial effect
Page 56 and 57: Women on 17β oestradiol implants,
Page 58 and 59: A Novel ERTMenoring ®• Intravagi
Page 60 and 61: Menoring ® Pharmacokinetics• Est
Page 62 and 63: HRT Delivery SystemsVaginal - rings
Page 64:
HRT Delivery SystemsVaginal - gels
Page 67 and 68:
New delivery vehicles for progestog
Page 69 and 70:
HRT delivery systemsConclusions•
Page 71:
Thank you for your attention!
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Role of Mirena in HRT - Nick Panay

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