Role of Mirena in HRT - Nick Panay

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Role of ERα and ERβ in Body Organ SystemsCentral nervous system:beta and alphaOvary: beta and alphaBlood vessels: betaBone: betaLungs: betaUrogenital tract: betaBreast: alphaLiver: alphaUterus: alphaCouse et al. 1997, Shughrue et al. 1996, Arts et al. 1997alphabeta
Raloxifene : Risk of Breast CancerPercentage of Randomized Patients1.51.00.50.00 1 2 3 4Cummings et al. JAMA. 1999; 281: 2189-2197Years Since RandomizationPlacebo4.3 per 1000 women yrsRR = 0.35 (0.21, 0.58)Raloxifene1.5 per 1000 women yrsp < 0.001
Page 1 and 2: HRTNew delivery systemsImperial Col
Page 3 and 4: New delivery systems for HRT• Pha
Page 5 and 6: New delivery systems for HRT• Des
Page 7 and 8: Routes of AdministrationAdvantagesO
Page 9 and 10: HRTVaginal PreparationsP• Product
Page 11 and 12: HRT Delivery SystemsIntranasal
Page 13 and 14: Aerodiol - intranasal HRT• 17 Bet
Page 15 and 16: Aerodiol: “pulsed” pharmacokine
Page 17 and 18: Tissue response to pulsed oestrogen
Page 20 and 21: Schematic representations of kineti
Page 22 and 23: ANGELIQ ®Comparison of Drospirenon
Page 24 and 25: Red Clover
Page 26 and 27: HRT: Maximising EfficacyMinimising
Page 28 and 29: Selectiveelective oEstrogenReceptor
Page 32: HRT: Maximising EfficacyMinimising
Page 35 and 36: Specific binding affinities:nuclear
Page 37 and 38: HRT Delivery SystemsSkin - patches
Page 39: HRT delivery systems - skinTransder
Page 42 and 43: HRT delivery systems - skin• Matr
Page 44: HRT Delivery SystemsSkin - creams/g
Page 48 and 49: HRT Delivery SystemsSubcutaneous im
Page 50 and 51: HRT Delivery SystemsUterine systems
Page 52 and 53: Mirena - mechanism of action
Page 54 and 55: Mirena - endometrial effect
Page 56 and 57: Women on 17β oestradiol implants,
Page 58 and 59: A Novel ERTMenoring ®• Intravagi
Page 60 and 61: Menoring ® Pharmacokinetics• Est
Page 62 and 63: HRT Delivery SystemsVaginal - rings
Page 64: HRT Delivery SystemsVaginal - gels
Page 67 and 68: New delivery vehicles for progestog
Page 69 and 70: HRT delivery systemsConclusions•
Page 71: Thank you for your attention!

Role of Mirena in HRT - Nick Panay

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