Glenn M. PremingerPNL to SWL for staghorn stone management demonstratedstone-free rates with initial PNL to be more thanthree times greater than with SWL monotherapy. Themainstay of any form or combination or multi-modaltherapy should be endoscopic removal. This approachallows removal of a high volume of stone as well as anaccurate assessment of stone-free status. SWL may beutilized in cases where remaining stones cannot bereached with flexible nephroscopy or safely approachedvia another access tract. However, total removal of fragmentsfrom the collecting system after SWL without subsequentnephroscopy is unlikely. Extremely low stonefreerates have been reported for combination approacheswhere SWL was the last combination procedure.Therefore, <strong>per</strong>cutaneous nephroscopy should be the lastpart of a combination therapy sequence as it allows forbetter assessment of stone-free status and a greaterchance of achieving this state.REFERENCES1. Meretyk S, Gofrit ON, Gafni O, et al. Complete staghorn calculi:Random prospective comparison between extracorporeal shockwave lithotripsy monotherapy and combined with <strong>per</strong>cutaneousnephrostolithotomy. J Urol 1997; 157:780-786.2. Preminger GM, Assimos DG, Lingeman JE, et al. Chapter 1:AUA guideline on management of staghorn calculi: Diagnosis andtreatment recommendations. J Uro 2005; 173:1991-2000.3. Hegarty NJ, Desai MM. Percutaneous nephrolithotomy requiringmultiple tracts: comparison of morbidity with single-tract procedures.J Endourol 2006; 20:753-60.CorrespondenceGlenn M. Preminger, MDDepartment of Urologic SurgeryDUMC Box 3167, Room 1572D, White ZoneDuke University Medical CenterDurham, North Carolina 27710, USAglenn.preminger@duke.edu40Archivio Italiano di Urologia e Andrologia 2010; 82, 1
PRESENTATIONEndoscopic combined intrarenal surgeryfor high burden renal stones.Cesare Marco Scoffone, Cecilia Maria Cracco, Massimiliano Poggio,Roberto Mario ScarpaDepartment of Urology, San Luigi University Hospital, Orbassano, Torino, Italy<strong>Summary</strong>“High burden stones” include single or multiple large calculi (altogether surfacearea > 300 mm 2 , or largest diameter > 20 mm), and staghorn calculi (any branched stoneoccupying more than one portion of the renal collecting system, i.e. pelvis with one ormore calyceal extensions). Since clinically threatening, their active removal is mandatory.All updated guidelines recommend four modalities as potential treatment forlarge/staghorn urolithiasis, including PNL monotherapy, ESWL monotherapy, combinations ofPNL and ESWL, and open surgery. The technical enhancement and increasing spread of PNL,ESWL and ureteroscopy in the past twenty years has led to displacement of the surgical therapy ofrenoureteral calculi in the daily urological practice (nowadays 1-5.4% of cases in developed countriesand in well-equipped, dedicated centres), but open or laparoscopic management of urolithiasisis still a viable option that should be considered in few, highly selected circumstances.Currently, PNL is the preferred first-line, minimally invasive treatment for complete one-stepremoval of high burden urolithiasis. It has been suggested that two or more access sites may berequired for complete clearance, yet implying greater blood loss. The use of single-tract PNL withadjuvant procedures such as flexible ureteroscopy/nephroscopy may decrease the disadvantagesof the multiple-tract PNL without compromising on stone-free rates. ECIRS (= endoscopic combinedintrarenal surgery) is a new, versatile approach for the treatment of large and/or complexurolithiasis. Combining the anterograde and retrograde approach to the renal cavities, ECIRSallows the combined use of all the rigid and flexible endourological armamentarium, and optimalendovision <strong>per</strong>cutaneous renal puncture, preliminary evaluation of renal stones features, negligibleneed of multiple <strong>per</strong>cutaneous accesses, immediate treatment of concomitant ureteral calculior ureteropyelic junction stenoses; final visual control of the stone-free status. ECIRS is usually<strong>per</strong>formed in the Galdakao-modified supine Valdivia position, the only patient position supportingthis comprehensive attitude of the urologist towards up<strong>per</strong> urinary tract pathologies. Optimalplanning of a safe and effective ECIRS procedure also benefits from an accurate preliminary threedimensionalstudy by means of tomography urography of the pelvicalyceal anatomy (which iscomplex and often highly variable) and of the stone features (site, number, size).KEY WORDS: PNL; Ureteroscopy; Large stones.Submitted 9 May 2009; Accepted 30 June 2009“High burden stones” include single or multiple large calculi(altogether surface area > 300 mm 2 , or largestdiameter > 20 mm, according to EAU Guidelines 2008for Urolithiasis), and staghorn calculi (any branchedstone occupying more than one portion of the renal collectingsystem, i.e. pelvis with one or more calycealextensions).Over time, high burden stones will cause progressiverenal deterioration, pyonephrosis, obstruction, flankpain, and/or life-threatening sepsis, therefore their activeremoval is mandatory.All updated guidelines recommend four modalities aspotential treatment for large/staghorn urolithiasis,including PNL monotherapy, ESWL monotherapy, combinationsof PNL and ESWL (sandwich therapies), andopen surgery, which should be part of the urologist’sskills. Indeed, the technical enhancement and increasingspread of PNL, ESWL and ureteroscopy in the past twen-Archivio Italiano di Urologia e Andrologia 2010; 82, 141
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