Jean- Christophe Thalabard: Curriculum Vitae

Jean- Christophe ThalabardProfessor & Senior Clinical ConsultantUniversité Paris DescartesMAP5, UMR CNRS 814545, rue des Saints Pères75006, ParisTel: (33)(0)1.42.86.25.15Fax: (33)(0)1.42.86.41.14Email: jean-christophe.thalabar@mi.parisdescartes.frHomepage: http://www.mi.parisdescartes.fr/∼thalabardUnité Gynécologie- EndocrinologieHôpital Cochin- Port- Royal53, Ave de l’Observatoire 75014, ParisTel: (33)(0)1.58.41.35.50Email: jean-christophe.thalabar@htd.aphp.frPersonal DataBorn 1950, 1st Julyin La Baule- Escoublac (44)French NationalityMarried, 4 childrenGraduate & Post Graduate Education1972: Graduate Ecole Polytechnique, Paris (X 1969)1972: Master in Mathematics & Probability (Pr Neveu, Azema, Revuz), University Paris 61974: Graduate Ecole Nationale des Ponts & Chaussées, Paris (Civil Engineering)1983: Medical Doctorate cum Laude University Paris 51983: Post graduate degree in Chronobiology, University Paris 51983: Master degreee in Biostatistics & Epidemiology (Pr. D Schwartz), University Paris 111979- 1983: Residency in Obstetrics & Gynecology, Paris1985: Board qualified in Obstetrics and Medical Gynecology1987: PhD in Human Biology cum laude University Paris 5Past Clinical Training & Positions1979-1983: Residency, AP-HP Paris Hospitals1983-1985: Chef de Clinique-Assistant. Endocrinology & Reproductive Medicine, Necker Hospital, Paris1985-1987: Medical Consultant, Endocrinology & Reproductive Medicine, Necker Hospital, Paris

Jean- Christophe Thalabard 21989-1996: Professor of Biostatistics, Lyon Medical School, Lyon 1 UniversitySenior Consultant in the Department of Clinical Pharmacology, Hospices Civils de Lyon (Pr. JP Boissel)1996- 2005: Professor of Biostatistics, Necker Medical School, Paris 5 UniversitySenior Consultant in Endocrinology & Reproductive Medicine, Department of Endocrinology & ReproductiveMedicine, Necker Hospital, AP-HP (Paris)2002- 2005: Head Clinical Research Organization (CRO), Necker Hospital, ParisPresent Positions2005- 2012: Professor of Biostatistics, Paris Descartes UniversitySenior Consultant in Endocrinology & Medical Gynecology, Diagnostic Center, Hôtel- Dieu, Paris2012- : Professor of Biostatistics, Paris Descartes UniversitySenior Consultant in Endocrinology & Medical Gynecology, Cochin Port- Royal, ParisPast Teaching & Research Positions1974- 1976: Teaching Assistant, Probability . Ecole Nationale des Ponts et Chaussées1973- 1973: Teaching Assistant. Biostatistics. Medical School, Lyon 1 University1974- 1983: Teaching Assistant, Biophysics, Cochin Medical School, Paris 5 University1974- 1983: Member ERA-CNRS 498 Biological Signal Processing (Pr. Perrin)1985-1989 : Senior Research Scientist at INSERM.Inserm Unit 21 (Head : Pr D. Schwartz)Inserm Unit 292 (Head : Pr A. Spira)1987- 1989 : On leave at the University of Texas at Houston (UTMSH) Laboratory for Neuroendocrinology,Head : P. E. Knobil).1988-1989: Adjunct Assistant Professor. Department of Physiology and Cell Biology. University ofTexas Health Science center.1990-1995: Visiting Professor. Dept. Of Physiology and Cell Biology. University of Texas Health ScienceCenter at Houston.1992-1996: Member URA CNRS 1458 "Neuroendocrinology" (Head : Pr Dubois), Lyon 1 University, Lyon2006- Present: Member UMR CNRS 8145, MAP5 Mathématiques Appliquées, Paris Descartes University,ParisCommittees1991-1994: INSERM committee for Clinical Research1991-1996: WHO Task force member Natural methods in fertility regulation1992-1996: Coordonnator of the College of Biostatisticians, Lyon 1 University1994-1998: Inserm committee Health, Population, Society1995-1999: Member of the Inserm permanent office for Clinical Research1999-2003: President of the Inserm permanent office for Clinical Research1997-1998: Expert for the INCO-Copernicus program of the European Community (Brussels)1992-2003: Member, INRETS Scientific Committee1994-2009: President of the INRETS ethical committee2000-2006: Member, Executive committee of the French National Network for Technologies in Health(RNST)

Jean- Christophe Thalabard 32001-2009: Expert for the "Délégation Régionale à la Recherche Clinique APHP"2001-2007: Member Prospective Committee of the French Council for Fight against Doping in Sports(CFLD)2007-2009: Member Scientific Committee & Prospective Committee of the French Anti- Doping Agency(AFLD)Sept 2001: Member Evaluation Committee for Research Infrastructure in Quebec(FRSQ, Canada).2002-2005: Head Clinical Research Unit, Necker Hospital, Paris2003-2011: Member Internal Review Board Inserm (CQI)2003-2006: Member COSSEC-INSERM2003-2008: Member AFSSAPS Scientific Advisory Board on Cell Therapies2009- present: Member Scientific Committee, Department of Applied Mathematics & Informatics, ParisDescartes University2006-present: Member, Scientific Advisory Board CNAMTS (French National Health Insurance Systemfor Employees)2009- present: Member Executive Committee IDSI (Institut Développement et Solidarité Internationale,Paris Descartes - Head: Pr. Y Charbit)2007- 2012: Coordinator, Action Thématique Programmée (ATP) "Biomathematics, biostatistics, Syntheticbiology" Paris Descartes university2011- present: Ligue Nationale Contre le Cancer (LNCC)- member of the Epidemiology & Public Healthresearch funding committee2011: HAS Expert Committee on breast cancer screening2011- 2012: HAS expert committee on Hormonal Replacement Therapy2012- INCA "Commission des études et recherches de la convention AERA"S. Working group on CancersInternational CurriculumSummer 1970: Russian learning school, Lomonossov University, Moscow (Russia)Summer 1971: International Student Exchange Program. Majed Factory, Lodz (Polen)Summer 1982: N.A.T.O. Summerschool on Pineal Gland. Erice (Italie)1987-1989: University of Texas Medical School at Houston1990-1992: French- Flemish Joint Program. Lab. Dr. J.M. Kaufman. Ghent. BelgienFebruary 1990: Ipsen Grant: Medical school, Yokohama, JaponJuly 1995: Grant from the Japanese Society for the promotion of Science, Royal University, Tokyo, Japan2007-2008: French - Norvegian Collaborative grant Aurora MAE2008- present: Department of Public Health & Family Medicine, Tromso Medical School (Norway): Pr. E.Lund Collaborative program on Epidemiology of Breast Cancer2009- present: Edulink Support Grant Stafav Master program: Universities Yaounde 1 (Cameroun),Abomey Calavi (Benin), Saint Louis (Senegal), Paris Sud University (France), Paris Descartes University(France)

Jean- Christophe Thalabard 4Scientific SocietiesMember International Society for Clinical Biostatistics (ISCB), member of the executive committee 2009-2011Member of the French Society for the Study of Mammary DiseasesMember of the French Endocrine SocietyMember of the French College of Biostatisticians (CIMES)Member of the French Statistical Society (SFdS)Member of the French Speaking Epidemiologist Association (ADELF)Foreign LanguagesEnglish read, written, spokenGerman read, writtenRussian read, writtenTrack-Record 2007-2012Publications in peer- reviewed journalsJulien Stirnemann, Adeline Samson, and JC Thalabard. Density estimation of a biomedical variable subjectto measurement error using an auxiliary set of replicate observations. Statistics in Medicine: in press, 2012Solange Whegang Youdom, Adeline Samson, Leonardo Basco, and JC Thalabard. Multiple treatment comparisonsin a series of anti-malarials trials with an ordinal primary outcome and repeated treatment evaluations.Malaria J,11 :147,2012.Julien Stirneman, Adeline Samson, and JC Thalabard. Individual predictions based on nonlinear mixedmodeling: application to prenatal twin growth. Statistics in Medicine: in press, 2012.Kim-Hanh Le Quan Sang, Jean-Baptiste Arnoux, Asmaa Mamoune, Cécile Saint-Martin, Christine Bellanne-Chantelot, Vassili Valayannopoulos, Anaïs Brassier, Honorine Kayirangwa, Valérie Barbier, Christine Broissand,Jean-Roch Fabreguettes, Brigitte Charron, Jean-Christophe Thalabard, and Pascale de Lonlay. Successfultreatment of congenital hyperinsulinism with long-acting release octreotide. Eur J Endocrinol, 166 :333-339, 2012.Mihaela Matei, Jean-Christophe Thalabard, Anne Laude, Christophe Misse, and Olivier Chassany. Researchon usual care: Assessing the qualification criteria of the current legal framework. Presse Med, 40(4 Pt 1):e189–e196, 2011.Solange Youdom Whegang, Leonardo K Basco, Henri Gwét, and Jean-Christophe Thalabard. Analysis of anordinal outcome in a multicentric randomized controlled trial: application to a 3- arm anti- malarial drugtrial in cameroon. BMC Med Res Methodol, 10:58, 2010.Phalla Ou, David S Celermajer, Davide Marini, Gabriella Agnoletti, Pascal Vouhé, Francis Brunelle, Kim-Hanh Le Quan Sang, Jean Christophe Thalabard, Daniel Sidi, and Damien Bonnet. Safety and accuracyof 64-slice computed tomography coronary angiography in children after the arterial switch operation fortransposition of the great arteries. JACC Cardiovasc Imaging, 1(3):331–339, 2008.Nathalie Boddaert, Kim Hanh Le Quan Sang, Agnès Rötig, Anne Leroy-Willig, Serge Gallet, Francis Brunelle,Daniel Sidi, Jean-Christophe Thalabard, Arnold Munnich, and Z. Ioav Cabantchik. Selective iron chelationin friedreich ataxia: biologic and clinical implications. Blood, 110(1):401–408, 2007.

Jean- Christophe Thalabard 5Research monographs, chapters in collective volumesJC Thalabard. Savoir technique, savoir médical: une union féconde in Formes, systèmes et milieux techniques DParrochia Ed, J André Collection Theriaka, 2012.JC Thalabard, and A Vanier Pratiques médicales, pratiques psychanalytiques: autorités et discours in Entre autoritéet incertitude: moments critiques B Brun Ed, Collection Etudes freudiennes, 2012JC Thalabard, L Joubin, L Rosetta, and CGN Mascie-Taylor. Analysing the characteristics of the menstrual cycle infield situations in humans in Some methodological aspects in Reproduction and Adaptation. CGN Mascie- Taylor& L Rosetta Eds, Cambridge Univ.Press, 2011.JC Thalabard. Le placebo: un concept nécessaire? in Placebo: le remède des remèdes. P Maire & R Bousaingeon Eds,Theriaka Series. Jacques André Ed., 2008.RefereeHuman Reproduction, European Journal of Endocrinology, BMC, Revue Etudes Santé Publique, BulletinEpidémiologique Hebdomadaire (BEH)Granted patents:not applicableFundings IDSince 1993, I have been actively involved both as an expert of the methodology of clinical research in variousresearch funding agencies and as the methodologist in clinical research projects at all stages of their development.These projects were mostly in the academic world and concerned numeroux aspects of evaluation indifferent domains, including imaging.2002- 2005: Clinical Research Unit of the University Hospital Necker Enfants Malades: Founder andfirst coordinator with one full time senior project manager (Dr. Kim-Hanh Le Quan Sang), one full timebiostatistician (Laurence Joubin), 4 full time clinical research assistantsAnnual recurrent dotation: 110 000 euros/yearResearch project fundings for a total 1 000 000 euros/ year2008: Coroscan TGV: Comparing non invasive dynamic scanner imaging versus angiocoronarography inthe follow up of children havind experienced vessel transposition at birth. Academic clinical researchprojet: PI Dr. P. Ou (radio- pediatrician, Necker University Hospital, Paris) 300 000 euros2009: A phase II trial comparing long acting monthly- versus daily- administration of sandostatine inchildren with congenital diazoxide- resistant hypersulinism. PI P de Lonlay, Necker University Hospital,Paris. Clinical Research Funding 90 000 euros2008: Evaluation médico-économique de la mis en place de l’analyse exhaustive de l’ADN mitochondrial(ADNmt) par les techniques Surveyor et Mitochips. French National Funding Program for the diffusionof Innovation in Medicine, PI: Pr. V Paquis-Flucklinger (Nice), Co- investigator 15 000 euros2008- 2012: Principal Coordinator "Mathematical Modeling, Biostatistics, Bioinformatics & System Biology"Special Funding for Transdiciplinary Incentive Actions (ATP), Paris Descartes University. 15000euros/ year2007: AP-HP Clinical Research Funding: Evaluation of Observational clinical research projets in routinecares according to the evolution of the french regulation. PI JC Thalabard, 70 000 eurosBringing togetherAs full member of the CNRS research unit # 8145 in applied mathematics (MAP5) and Senior medicalconsultant in an university hospital, with a large experience in coordinating research projects involvingboth healthy and non- healthy subjects, a large part of my activities is devoted to bridge the gap betweenthe clinical research world and the mathematical world, more specifically in applications of statistics andinformatics.I directly initiated two major actions which are still on going

Jean- Christophe Thalabard 6Transcriptomics in Cancer Epidemiology (TICE) project coordinated by Pr. E Lund (University ofTromso, Norway) funded by an EU advanced investigation grant, involving as far as the methodologicalaspects are concerned teams from Norway (Tromso, Oslo), Israel (Tel Aviv, Haifa), Italy (Catania)and France (MAP5, Paris)Joint work on the pharmacogenomics of the non polypous colic cancers and therapeutical responsewith Pr. P Laurent- Puig (Inserm UMR S-776 & APHP)2006- present: Inserm special MD- PhD program. In charge of the Mathematics and Medicine course2008- present: PRES Sorbonne Paris Cité MD- PhD program. In charge of the Mathematics and Medicinecourse2009- present: Interdisciplinary Approach to Life Science (AIV) master program. In charge of the Science& Medicine SeminarMaster and PhD supervisionMaster internship supervisionJ Stirnemann, 2007S Zitoun, 2008J Taniou, 2009K Yauy, 2011PhD supervisionS Whegang, 2007- 2010. PhD defended October 2010.J Stirnemann, 2009- 2012Organisation of International conferences and seminarsInternational Society for Clinical Biostatistics2009- 2011: Member executive committeeAnnual international congress, Montpellier, 2010: member of the young scientist award selection committeeand in charge of the final financial internal auditAnnual international congress, Ottawa, 2011: member of the scientific program committee & Youngscientist award selection committee Ottawa, 2011Last updated: May 6, 2012http://www.math-info.univ-paris5.fr/∼thalabard