LACULAX SOLUTION 100ml - Lomus Pharmaceuticals Pvt. Ltd.

LACULAX SolutionDosage Forms/CompositionSolution: Each 5ml contains Lactulose 3.35gmPharmacological IndexAmmonium Detoxicant; Laxative, MiscellaneousINDICATIONAdjunct in the prevention and treatment of portal-systemic encephalopathy (PSE);treatment of chronic constipation.Pregnancy Risk FactorBContraindicationsPatients with galactosemia and require a low galactose diet, hypersensitivity to anycomponent.Warnings/PrecautionsUse with caution in patients with diabetes mellitus; monitor periodically for electrolyteimbalance when lactulose is used >6 months or in patients predisposed to electrolyteabnormalities (eg, elderly); patients receiving lactulose and an oral anti-infective agentshould be monitored for possible inadequate response to lactulose.Adverse Reactions>10%: Gastrointestinal: Flatulence, diarrhea (excessive dose).1% to 10%: Gastrointestinal: Abdominal discomfort, nausea, vomiting.Overdosage/ToxicologySymptoms of overdose include diarrhea, abdominal pain, hypochloremic alkalosis,dehydration, hypotension, hypokalemia. Treatment includes supportive care.Drug InteractionsDecreased effect: Oral neomycin, other laxatives, antacids.Mechanism of ActionThe bacterial degradation of lactulose resulting in an acidic pH inhibits the diffusion ofNH3 into the blood by causing the conversion of NH3 to NH4+; also enhances thediffusion of NH3 from the blood into the gut where conversion to NH4+ occurs;produces an osmotic effect in the colon with resultant distention promoting peristalsis.Pharmacodynamics/KineticsAbsorption: Oral: Not absorbed appreciably following administration; this is desirablesince the intended site of action is within the colon.Metabolism: By colonic flora to lactic acid and acetic acid, requires colonic flora for

primary drug activation.Elimination: Primarily in feces and urine (~3%)Usual DosageConstipation:15-45 ml per day depending on the severity of the condition.Hepatic encephalopathy:30-50 ml three times a day.Patient InformationNot for long-term use. Take as directed, alone, or diluted with water, juice or milk, ortake with food. Laxative results may not occur for 24-48 hours; do not take more oftenthan recommended or for a longer time than recommended. Do not use any otherlaxatives while taking lactulose. Increased fiber, fluids, and exercise may help reduceconstipation. Do not use if experiencing abdominal pain, nausea, or vomiting. Diarrheamay indicate overdose. May cause flatulence, belching, or abdominal cramping. Reportpersistent or severe diarrhea or abdominal cramping. Breast-feeding precautions:Consult prescriber if breast-feeding.LOMUS Drug Information CenterLomus Pharmaceuticals Pvt. Ltd.P.O. Box No 4506, Lomus House (Corporate office),Kailash Chour, Lazimpat, Kathmandu, NepalPh: 4436396 (Hunting Line). Fx: 977-1-4436395E-mail: druginfo@lomus.com.np