Are Bcr-Abl KD mutations already detectable at the time ... - siesonline

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Results (IV)55/61(90%) nucleotide substitutions were transitionsTransitions:G>AA>GT>CC>TTotalTransversions:G>TA>TT>AT>GA>CTotal1514131355211116Such a high prevalenceof transitions (whichnormally occur 1.4 timesmore frequently thantransversions) suggeststhat a specific mechanismgenerating mutations ispredominant
Take-home messagesa) Bcr-Abl KD mutations can probably be found at thetime of diagnosis in all Ph+ ALL ptsb) TKI-resistant mutations present at low levels atdiagnosis do not always outgrow and lead to relapse,probably because some of them arise in cell cloneswith limited self-renewal capacityc) It is essential to understand the molecularmechanism(s) sustaining this “mutator phenotype” aswell as how to therapeutically interfere with them
Page 1 and 2: LAL:significato clinico e biologico
Page 3 and 4: Imatinib-resistant pts with Ph+ ALL
Page 5 and 6: Second-line TKIs in imatinib resist
Page 7 and 8: In ALL genetic instability is high
Page 9 and 10: Are Bcr-Abl KD mutations alreadydet
Page 11 and 12: Patients (II)NSexAgeBcr-Abl typeSta
Page 13 and 14: Results (I)Aberrant Bcr-Abl KD sequ
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Are Bcr-Abl KD mutations already detectable at the time ... - siesonline

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