Are Bcr-Abl KD mutations already detectable at the time ... - siesonline

Are Bcr-Abl KD mutations alreadydetectable at the time of diagnosis?• German experience: Bcr-Abl KD mutations detected by D-HPLC at the time of diagnosis in:- 9/22 (41%) cases in elderly pts (Pfeifer et al, Blood 2007)– 6/34 (18%) cases in younger pts (Pfeifer et al, EHA 2008)• Lower detection limit of D-HPLC is routinely 5-10%• What happens if we increase the sensitivity of ourscreening method?