Are Bcr-Abl KD mutations already detectable at the time ... - siesonline

Take-home messagesa) Bcr-Abl KD mutations can probably be found at thetime of diagnosis in all Ph+ ALL ptsb) TKI-resistant mutations present at low levels atdiagnosis do not always outgrow and lead to relapse,probably because some of them arise in cell cloneswith limited self-renewal capacityc) It is essential to understand the molecularmechanism(s) sustaining this “mutator phenotype” aswell as how to therapeutically interfere with them