QSAR & QSPR
QSAR & QSPR
QSAR & QSPR
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Steric effectsTaft quantified the steric (spatial) effects using the hydrolysis of esters:Here, the size of R affects the rate of reaction by blocking nucleophilic attack by water.In this case, the steric effects were quantified by the Taft parameter E s :k is the rate constant for ester hydrolysis. This expression is analogous to the Hammett equation.