QSAR & QSPR
QSAR & QSPR
QSAR & QSPR
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History of <strong>QSAR</strong>• 1868, D. Mendeleev – The Periodic Table of Elements• 1868, A. Crum-Brown and T.R. Fraser – formulated a suggestion thatphysiological activity of molecules depends on their constitution:Activity = F(structure)They studied a series of quaternized strychnine derivatives, some ofwhich possess activity similar to curare in paralyzing muscle.• 1869, B.J. Richardson – narcotic effect of primary alcohols varies inproportion to their molecular weights.
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