QSAR & QSPR

Example of oral administration:– Drug is exposed to a large varietyof pH values:• Saliva pH 6.4• Stomach pH 1.0 – 3.5• Duodenum pH 5 – 7.5• Jejunum pH 6.5 – 8• Colon pH 5.5 – 6.8• Blood pH 7.4– „Liver-first-pass-effect“www.3dscience.com