QSAR & QSPR
QSAR & QSPR
QSAR & QSPR
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History of <strong>QSAR</strong>• 1937, L.P. Hammett studied chemical reactivity ofsubstituted benzenes:Hammett equation,Linear Free Energy Relationship (LFER)• 1939, J. Fergusson formulated a concept linking narcoticactivity, logP and thermodynamics.• 1952- 1956, R.W. Taft devised a procedure for separatingpolar, steric and resonance effects.