Celiac Disease - NIH Consensus Development Program - National ...

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Contents Introduction......................................................................................................................................1 Agenda .............................................................................................................................................3 Panel Members.................................................................................................................................9 Speakers .........................................................................................................................................11 Planning Committee.......................................................................................................................13 Abstracts ........................................................................................................................................17 I. How Is Celiac Disease Diagnosed?Overview and Pathogenesis of Celiac Disease Martin F. Kagnoff, M.D. .............................................................................................................19 The Pathology of Celiac Disease Paul J. Ciclitira, M.D., Ph.D., FRCP..........................................................................................23 What Are the Sensitivity and Specificity of Serological Tests for Celiac Disease?Do Sensitivity and Specificity Vary in Different Populations? Ivor D. Hill, M.D. .........................................................................................................................27 Clinical Algorithm in Celiac DiseaseCiaran P. Kelly, M.D. ..................................................................................................................33 Genetic Testing: Who Should Do the Testing and What Is the Role of Genetic Testing in the Setting of Celiac Disease? George S. Eisenbarth, M.D. ........................................................................................................37 Serological Testing for Celiac Disease Alaa Rostom, M.D., M.Sc., FRCPC ...........................................................................................41 II. How Prevalent Is Celiac Disease?Epidemiology of Celiac Disease: What Are the Prevalence, Incidence, and Progression of Celiac Disease? Marian J. Rewers, M.D., Ph.D....................................................................................................45 What Are the Prevalence and Incidence of Celiac Disease in High-Risk Populations: Patients With an Affected Family Member, Type 1 Diabetes, Iron-Deficiency Anemia, and Osteoporosis? Joseph A. Murray, M.D...............................................................................................................49 Incidence and Prevalence of Celiac Disease Alaa Rostom, M.D., M.Sc., FRCPC ...........................................................................................57 iii
III. What Are the Manifestations and Long-Term Consequences of Celiac Disease?Clinical Presentation of Celiac Disease in the Pediatric Population Alessio Fasano, M.D.....................................................................................................................61 The Many Faces of Celiac Disease: Clinical Presentation of Celiac Disease in the AdultPopulation Peter H.R. Green, M.D. ...............................................................................................................65 Association of Celiac Disease and Gastrointestinal (GI) Lymphomas and Other GI Cancers Carlo Catassi, M.D., M.P.H. .......................................................................................................69 Skin Manifestations of Celiac Disease John J. Zone, M.D........................................................................................................................73 Neurological/Psychological Presentation of Celiac Disease: Ataxia, Depression, Neuropathy, Seizures, and Autism Khalafalla O. Bushara, M.D. ......................................................................................................77IV. Who Should Be Tested for Celiac Disease?Should Children Be Screened for Celiac Disease? Is There Evidence To Support the Strategy of Screening All Children?Edward J. Hoffenberg, M.D........................................................................................................79 Should Adults Be Screened for Celiac Disease? What Are the Benefits and Harms of Screening?Pekka Collin, M.D., Ph.D. ...........................................................................................................83 Consequences of Testing for Celiac Disease Ann Cranney, M.D., M.Sc...........................................................................................................87 V. What Is the Management of Celiac Disease?Dietary Guidelines for Celiac Disease and Implementation Cynthia Kupper, R.D., C.D.........................................................................................................91 How To Provide Effective Education and Resources: Gluten-Free Diets Shelley Case, R.D. ........................................................................................................................97 The Followup of Patients With Celiac Disease⎯Achieving Compliance With Treatment Michelle Maria Pietzak, M.D....................................................................................................103 iv
Page 1: NIH Consensus Development Conferenc
Page 5 and 6: • What is the management of celia
Page 7 and 8: Monday, June 28, 2004 (continued)I.
Page 9 and 10: Monday, June 28, 2004 (continued)II
Page 11 and 12: Wednesday, June 30, 2004 (continued
Page 13 and 14: Lisa H. RichardsonConsumer Represen
Page 15 and 16: Ciaran P. Kelly, M.D.Director, Celi
Page 17 and 18: Van S. Hubbard, M.D., Ph.D.Director
Page 19 and 20: AbstractsThe following are abstract
Page 21 and 22: susceptibility (e.g., DR17 homozygo
Page 23 and 24: The Pathology of Celiac DiseaseDavi
Page 25 and 26: In this regard, the transport pathw
Page 27 and 28: for the IgG-based test, while speci
Page 29 and 30: 15. de Lecea A, Ribes-Koninckx C, P
Page 31 and 32: Clinical Algorithm in Celiac Diseas
Page 33 and 34: Considera diagnosisof celiac diseas
Page 35 and 36: There are populations at particular
Page 37 and 38: Serological Testing for Celiac Dise
Page 39 and 40: Estimates of the sensitivity of the
Page 41 and 42: the risk and severity of CD may als
Page 43 and 44: What Are the Prevalence and Inciden
Page 45 and 46: ascribed to excess menstrual loss.
Page 47 and 48: ReferencesFamily History of Celiac
Page 49 and 50: Carroccio A, Iannitto E, Cavataio F
Page 51 and 52: identified by surveys or through so
Page 53 and 54:
Clinical Presentation of Celiac Dis
Page 55 and 56:
een widely reported. The question r
Page 57 and 58:
The Many Faces of Celiac Disease: C
Page 59 and 60:
References1. Green PH, Jabri B. Coe
Page 61 and 62:
Association of Celiac Disease and G
Page 63 and 64:
Does the Gluten-Free Diet Protect F
Page 65 and 66:
Skin Manifestations of Celiac Disea
Page 67 and 68:
allow a better understanding of the
Page 69 and 70:
4. Henriksson KG, Hallert C, Walan
Page 71 and 72:
characterized, clinically-identifie
Page 73 and 74:
10. Hoffenberg EJ, Emery LM, Barrig
Page 75 and 76:
ataxia, epilepsy with posterior cer
Page 77 and 78:
Consequences of Testing for Celiac
Page 79 and 80:
Osteoporosis/FracturesThere were 11
Page 81 and 82:
Dietary Guidelines for Celiac Disea
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21. Thompson T. Thiamin, riboflavin
Page 88 and 89:
In order to effectively counsel ind
Page 90 and 91:
9. Hallert C, Granno C, Hulten S, M
Page 92 and 93:
adhered to the GFD after more than
Page 94 and 95:
Patient education, close supervisio
Page 96:
26. Mustalahti K, Lohiniemi S, Laip
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