A review of studies examining the relationship between progression ...

More documents

Recommendations

Info

Table 1: Characteristics of included papersReference Tumour type Study identification Inclusion criteria Number of studies Number of patientsLouvet 2001 22 Metastatic colorectal Not stated Phase III studies of first line treatment 29 13,498reported between 1990 and 2000, >100patients per study armHackshaw2005 24 Metastatic breast Systematic search(Medline 1966-2005)Randomised trials comparing FAC orFEC with one or more first-line42 9163Johnson 2006 9Metastatic colorectal,metastatic non-smallcelllungcombination therapiesSystematic search RCTs of first-line treatment Colorectal: 146Buyse 2007 14 Advanced colorectal Not stated but all hadindividual patient dataRCTs with a FU+leucovorin treatmentarm.Tang 2007 27 Metastatic colorectal Systematic search Randomised trials of first-linetreatment published between 1990 and2005, >100 patients per arm, maturedata on OS and either TTP or PFSBowater 2008 10 Metastatic breast, Systematic search for RCTs comparing two differentcolorectal, hormone reviews of RCT published chemotherapy treatmentsrefractory prostate between 1990 and 2007and non-small celllungBurzykowski Metastatic breast Not stated but all had2008 15 individual patient dataHotta 2009 26Miksad 2008 23Advanced ormetastatic non-smallcell lungAdvanced breast(some locallyadvanced included)Randomised trials comparinganthracycline with taxane(both single agent and combinationtherapy)Lung: 191Historical: 10Validation: 339 18,66833, 38, 23 and 13respectively by tumourtypeColorectal:35,557Lung:44,125Historical: 3089Validation; 1,263Not stated11 3,953Systematic search Phase III trials of first-line therapies 54 23,457Systematic searchRandomised controlled trials ofanthracyclines and taxanes31 4,323Sherrill 2008 11 Metastatic breast Systematic search RCTs published after 1994 67 17,08114
Reference Tumour type Study identification Inclusion criteria Number of studies Number of patientsWilkerson Metastatic solid “non-exhaustive” search Randomised trials showing a stat sig 66 Not stated2009 21 tumoursdifference in either PFS or OS or theirFoster 2010 17Bowater 2011 28Hotta 2011 25“Extensive” smallcelllungMetastatic breast,colorectal (includedif proportion hadlocally advanceddisease)Advanced ormetastatic non-smallcell lungConsecutive trials fromthe North Central CancerTreatment GroupSystematic literaturesearchHRsFirst-line trials (phase II and III) thatincluded either a platinum or taxolbased regimenRCTs published between 1998 and2008 comparing two differentchemotherapy treatments9 87095 and 74by tumour typerespectivelyNot statedSystematic search Phase III trials of first-line therapy 70 38,721Halabi 2009 16 Metastatic prostate Not stated Phase II and III multicentre trials 9 1,296conducted by CALGBHeng 2011 20 Metastatic renal cell Not relevant Consecutive population based samples Not relevant 1,158at 12 cancer centresPolley 2010 18 Brain (Glioblastoma Not relevantPhase II trials conducted at a single 3 193multiforme)institutionMandrekar Advanced non-small Not relevant Consecutive NCCTG phase II trials 4 2842010 19 cell lungChirila 2011 13 Metastatic colorectal Systematic search Randomised phase II and III trials with 62 23,527cancerat least 20 participantsFAC=5-fluorouracil, adriamycin and cyclophosphamide, FEC=5-fluorouracil, epirubicin and cyclophosphamide, RCT=randomised controlled trial, FU= fluorouracil, CALGB=Cancerand Leukemia Group B, NCCTG=North Central Cancer Treatment Group15
Page 1 and 2: A REVIEW OF STUDIES EXAMINING THE R
Page 3 and 4: EXECUTIVE SUMMARYIntroductionProgre
Page 5 and 6: CONTENTS1. INTRODUCTION ...........
Page 7 and 8: 1. INTRODUCTION1.1. BACKGROUNDProgr
Page 9 and 10: equivalent incremental benefit in O
Page 11: 2. REVIEW METHODS2.1. SEARCH STRATE
Page 16 and 17: Table 2: Methods used to analyse th
Page 18 and 19: Reference Data type Relationships a
Page 20 and 21: Reference Data type Relationships a
Page 22 and 23: 4.2. METHODS IN STUDIES USING INDIV
Page 24 and 25: 5.1. DEFINITION OF TREATMENT EFFECT
Page 26 and 27: 5.3. OTHER MEASURES OF CORRELATION
Page 28 and 29: The slope parameters in the linear
Page 30 and 31: Table 4: Summary of results by tumo
Page 33 and 34: many of the papers included in this
Page 35 and 36: 8. REFERENCES1. Therasse, P., Arbuc
Page 37 and 38: 25. Hotta, K., Kiura, K., Fujiwara,
Page 39 and 40: APPENDIX 2: SEARCH STRATEGIESThe in
Page 41: 38 26 or 27 or 28 or 29 (1206968)39

A review of studies examining the relationship between progression ...

Create successful ePaper yourself

Delete template?

Save as template?