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A review of studies examining the relationship between progression ...

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9. APPENDICESAPPENDIX 1: EXCLUDED STUDIESReferenceSaad E, Katz A, H<strong>of</strong>f P, Buyse M. Progression-free survival assurrogate and as true end point: insights from <strong>the</strong> breast andcolorectal cancer literature. Annals <strong>of</strong> Oncology 2010;21(1):7-12.Lee L. Identification <strong>of</strong> potential surrogate end points inrandomized clinical trials <strong>of</strong> aggressive and indolent non-Hodgkin's lymphoma: correlation <strong>of</strong> complete response, time-toeventand overall survival end points.[Article]. Annals <strong>of</strong>Oncology 2011;22(6):1392-1403.Broglio KR, Berry DA. Detecting an Overall Survival Benefitthat Is Derived From Progression-Free Survival. Journal <strong>of</strong> <strong>the</strong>National Cancer Institute (Cary) 2009;101(23):1642-1649.ReasonSystematic <strong>review</strong> reporting PFS and OSbut not <strong>examining</strong> <strong>relationship</strong> <strong>between</strong>PFS and OSTreatment has curative ra<strong>the</strong>r thanpalliative intentSimulated data38

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