A review of studies examining the relationship between progression ...

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Reference Data type Relationships analysed Methods used ResultsMiksad 2008 23 Summarydata fromtrialsHRs for PFS and OS Kappa tests for agreement in direction ofeffects (HRs)Fixed effects linear regression for LogHRs(weighted by sample size)Anthracyclines: Kappa=0.71 (0.36-1.00,p=0.0029)Taxanes: Kappa = 0.75 (0.42-1.00, p=0.0028)Anthracyclines: R 2 =0.49, p=0.0019Taxanes: R 2 = 0.35, p=0.012Sherrill 2008 11Summarydata fromtrialsTreatment effects forTTP/PFS and OS (HR-1)Linear model (through origin) on treatmenteffect, weighted by sample sizeUnweighted Pearson correlation betweenHazard ratiosSlope = 0.32 (95% CI: 0.20, 0.43), R 2 = 0.30R=0.46Significance of treatmenteffect in TTP/PFS and OSKappa test for agreement regardingsignificant treatment effectKappa=0.47, P
Reference Data type Relationships analysed Methods used ResultsBowater 2011 28 Summarydata fromtrialsSpearman’s rank correlation for %change,% gain in median TTP and %gain in PPS(PPS = median OS – medianTTP)Hypothesis (sign) test for proportion of trialswitha) PPS%gain < TTP%gain,b) PPS%gain
Page 1 and 2: A REVIEW OF STUDIES EXAMINING THE R
Page 3 and 4: EXECUTIVE SUMMARYIntroductionProgre
Page 5 and 6: CONTENTS1. INTRODUCTION ...........
Page 7 and 8: 1. INTRODUCTION1.1. BACKGROUNDProgr
Page 9 and 10: equivalent incremental benefit in O
Page 11: 2. REVIEW METHODS2.1. SEARCH STRATE
Page 14 and 15: Table 1: Characteristics of include
Page 16 and 17: Table 2: Methods used to analyse th
Page 20 and 21: Reference Data type Relationships a
Page 22 and 23: 4.2. METHODS IN STUDIES USING INDIV
Page 24 and 25: 5.1. DEFINITION OF TREATMENT EFFECT
Page 26 and 27: 5.3. OTHER MEASURES OF CORRELATION
Page 28 and 29: The slope parameters in the linear
Page 30 and 31: Table 4: Summary of results by tumo
Page 33 and 34: many of the papers included in this
Page 35 and 36: 8. REFERENCES1. Therasse, P., Arbuc
Page 37 and 38: 25. Hotta, K., Kiura, K., Fujiwara,
Page 39 and 40: APPENDIX 2: SEARCH STRATEGIESThe in
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