Prof. Dr. Thomas Höfer German Cancer Research Center (DKFZ ...
Prof. Dr. Thomas Höfer German Cancer Research Center (DKFZ ...
Prof. Dr. Thomas Höfer German Cancer Research Center (DKFZ ...
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<strong>Prof</strong>. <strong>Dr</strong>. <strong>Thomas</strong> <strong>Höfer</strong><br />
25/03/1967, <strong>Dr</strong>esden<br />
CURRICULUM VITAE<br />
<strong>German</strong> <strong>Cancer</strong> <strong>Research</strong> <strong>Center</strong> (<strong>DKFZ</strong>)<br />
69120 Heidelberg, <strong>German</strong>y<br />
Phone: +49-(0)6221 54 51380<br />
Fax: +49-(0)6221 5451487<br />
E-mail: t.hoefer@dkfz-heidelberg.de<br />
2006 – present <strong>Research</strong> Group Leader Modeling of Biological Systems, <strong>German</strong> <strong>Cancer</strong><br />
<strong>Research</strong> <strong>Center</strong> Heidelberg<br />
2005 Offer of Chair in Systems Biology, University of Warwick, UK (declined)<br />
2002 – 2006 Junior <strong>Prof</strong>essor of Theoretical Biophysics, Humboldt University Berlin<br />
1997 – 2002 Lecturer in biophysics, Humboldt University Berlin<br />
Extended research visits to Collège de France, Paris<br />
1996 – 1997 Postdoc, Max Planck Institute for Physics of Complex Systems, <strong>Dr</strong>esden<br />
1993 – 1996 PhD, <strong>Center</strong> for Mathematical Biology, University of Oxford<br />
1988 – 1993 Study of Biophysics, Humboldt University Berlin<br />
COORDINATING FUNCTIONS<br />
2007 – present Member of the DECHEMA Scientific Working Group Systems Biology<br />
2006 – present Speaker of the Scientific Advisory Board of the Stuttgart <strong>Center</strong> for<br />
Systems Biology<br />
2002 – present Member of the Executive Committee of the DFG Collaborative <strong>Research</strong><br />
<strong>Center</strong> SFB 618 Theoretical Biology<br />
2000 – present Organized several international workshops (e.g., Hiddensee Workshop on<br />
Signal Transduction and Gene Regulation 2004) and invited sessions at<br />
international conferences (e.g., at European Conference for Mathematical<br />
and Theoretical Biology, Milan 2002)<br />
FIELDS OF INTEREST<br />
Mathematical modeling of cellular processes, signal transduction, gene regulation, molecular<br />
immunology, systems biology<br />
CURRENTLY FUNDED PROJECTS<br />
BMBF-FORSYS ViroQuant, BMBF Competence Network Hepatosys (systems biology of<br />
hepatocyes); DFG: SFB 618 Theoretical Biology, SFB 555 Complex Nonlinear Processes,<br />
SFB 740 From Molecules To Modules, IRTG 1360 Genomics and Systems Biology of<br />
Molecular Networks, DAAD: PPP-USA
PUBLICATIONS (10 most important publications):<br />
Salazar, C. and <strong>Höfer</strong>, T. (2007) Versatile regulation of multisite protein phosphorylation by<br />
the order of phosphate processing and protein-protein interactions. FEBS J. 274,<br />
1046-1061.<br />
Politi, A., Gaspers, L.D., <strong>Thomas</strong>, A.P., and <strong>Höfer</strong>, T. (2006) Models of IP3 and Ca 2+<br />
oscillations: Frequency encoding and identification of underlying feedbacks. Biophys.<br />
J. 90, 3120-3133.<br />
<strong>Höfer</strong>, T., Mühlinghaus, G., Hiepe, F., Radbruch, A. et al. (2006) Adaptation of humoral<br />
memory. Immunol. Rev. 211, 295-302.<br />
Mariani, L., Löhning, M., Radbruch, A., and <strong>Höfer</strong>, T. (2004) Transcriptional control networks<br />
of cell differentiation: insights from T lymphocytes. Progr. Biophys. Mol. Biol. 86,<br />
45-76.<br />
Salazar, C. and <strong>Höfer</strong>, T. (2003) Allosteric regulation of the transcription factor NFAT1 by<br />
multiple phosphorylation sites: a mathematical analysis. J. Mol. Biol. 327, 31-45.<br />
Schuster, S., Marhl, M., and <strong>Höfer</strong>, T. (2002) Modelling of simple and complex calcium<br />
oscillations: From single-cell responses to intercellular signalling. Eur. J. Biochem.<br />
269, 1333-1355.<br />
<strong>Höfer</strong>, T., Nathanson, H., Löhning, M., Radbruch, A., and Heinrich, R. (2002) GATA-3<br />
transcriptional imprinting in Th2 lymphocytes: a mathematical model. Proc. Natl.<br />
Acad. Sci. USA 99, 9364-9368.<br />
<strong>Höfer</strong>, T., Venance, L., and Giaume, C. (2002) Control and plasticity of intercellular calcium<br />
waves in astrocytes: a modeling approach. J. Neurosci. 22, 4850-4859.<br />
<strong>Höfer</strong>, T. (1999) Model of intercellular calcium oscillations in hepatocytes: synchronization of<br />
heterogeneous cells. Biophys. J. 77, 1244-1256.<br />
<strong>Höfer</strong>, T. and Maini, P.K. (1996) Turing patterns in fish skin? Nature 380, 678.
EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES<br />
Supervision of PhD students: 6 current and 3 completed<br />
Member of numerous thesis and thesis advisory committees<br />
Organization of three research training workshops for PhD students in the DFG Graduate<br />
School Dynamics and Evolution of Cellular Processes (GK 268, Humboldt University<br />
Berlin)<br />
SUPERVISED DISSERTATIONS (last 5 years)<br />
Antonio Politi, PhD (2007) Systems biology perspectives on calcium signaling and DNA<br />
repair. Humboldt University Berlin<br />
Current occupation: Postdoctoral fellow, University of Auckland<br />
Stephan Beirer, PhD (2007) Mathematical modelling of the Jak-Stat1 signal transduction<br />
pathway. Humboldt-University Berlin<br />
Current occupation: Software consultant<br />
Carlos Salazar, PhD (2005) Regulation of signalling proteins by phosphorylation cycles: a<br />
theoretical approach. Humboldt University Berlin.<br />
Current occupation: Postdoctoral fellow, <strong>German</strong> <strong>Cancer</strong> <strong>Research</strong> <strong>Center</strong>, Heidelberg
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