Hand out sheet - Faculty of Medicine - มหาวิทยาลัยนเรศวร

12/4/2012Pasuporn Po‐ngernnakInnate Immunity• Epithelial barriers : block entry of microbesPasuporn Po‐ngernnak• Phagocytes: Neutrophil, Macrophage– Microbes are internalized and destroyed by reactive oxygen, hydrolyticenzymes, resulting in inflammation.• Dendritic cells, natural killer (NK) cells : anti‐viral defense• Complement proteins: most important plasma proteins of the innateimmunity• Lung surfactant, respiratory epithelium, mucus, cilia, cough reflexThe principal mechanisms of innate immunity and adaptive immunity. NK, natural killer.• Hydrochloric acid (HCl), GI epitheliumDownloaded from: Robbins Basic Pathology 9E (on 26 November 2012) © 2012 ElsevierAdaptive Immunity• Mainly consists of lymphocytes and theirproducts, including antibodiesPasuporn Po‐ngernnak• Cell‐mediated (cellular) immunity (T cell)– Defense against intracellular microbes• Humoral immunity (Antibody)– Defense against extracellular microbes and theirtoxinsDownloaded from: Robbins & Cotran Pathologic Basis of Disease (on 2 June 2009 11:29 AM)© 2007 Elsevier2