Hand out sheet - Faculty of Medicine - มหาวิทยาลัยนเรศวร

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12/4/2012B Lymphocytes• Bone marrow – derived, or “B” cells• 10‐20% in circulating blood, bone marrow, lymph nodes,spleen, tonsils, GI tract• After stimulation, B cells form “plasma cells” thatsecrete immunoglobulins (antibody)Pasuporn Po‐ngernnakPasuporn Po‐ngernnak• 5 basic Immunoglobulins isotypes: IgG, IgM, IgA, IgE, IgDDownloaded from: Robbins Basic Pathology 9E (on 26 November 2012) © 2012 Elsevier• Recognize antigen via monomeric surface IgM, “B‐cellreceptor (BCR)”B cell receptor complex is composed of membrane IgM and the associatedsignaling proteins Igα and Igβ.CD21 is a receptor for a complement component that promotes B cell activation.Ig, immunoglobulin; MHC, major histocompatibilty complexT lymphocytesPasuporn Po‐ngernnakT Lymphocytes• Thymus‐derived, or “T” cellsPasuporn Po‐ngernnak• Constitute 60‐70% of the lymphocytes incirculating blood, also in lymphoid organs• Recognized a unique processed peptide fragmentby T‐cell receptor (TCR)http://www.daviddarling.info/encyclopedia/T/T‐lymphocyte.htmlScanning electron micrograph of a T‐lymphocyte• TCR (>95%) is a protein heterodimer of disulfidelinkalpha‐ and beta‐ chains, complex with CD3moleculehttp://infosemata.blogspot.com/2012/08/jenis‐jenis‐leukosit.html4
12/4/2012T Lymphocytes• CD4+ T cells– “helper” T cells (TH1 & TH2)– Bind to class II MHC molecules on selected APCs– Secrete several cytokines (IL‐2, IFN‐alpha)– Proliferation and activation of other molecules (macrophages,NK cells, cytotoxic T cells)Pasuporn Po‐ngernnakPasuporn Po‐ngernnak• CD8+ T cells– “cytotoxic” T cells (TC1 & TC2)– Bind to class I MHC molecules– Directly killing virus‐infected or tumor cellsT‐cell receptor (TCR) complex and othermolecules involved in T‐cell activationDownloaded from: Robbins & Cotran Pathologic Basis of Disease 8 th (on 26 Nov 2012) Copyright © 2012 Elsevier Inc Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 2 June 2009 )Major Histocompatibility Complex (MHC)• เปนระบบของ membrane protein ที่มีความหลากหลายมากในหมูประชากร (polymorphism) มีบทบาทสําคัญในการปลูกถายอวัยวะและการปฏิเสธอวัยวะที่ปลูกถาย (Graft rejection)• MHC สําหรับในมนุษยอาจเรียกวา human leukocytes antigens (HLA)ซึ่งเปน antigen ที่จําเพาะสําหรับแตละคนPasuporn Po‐ngernnakHuman leukocyte antigen (HLA)• To bind peptide fragments of foreign proteins forpresentation to appropriate antigen specific T cells• Most important MHC genes clustered on chromosome 6,highly polymorphic• MHC gene products fall into 3 categories:1. Class I MHC2. Class II MHC3. Class III proteins (complement, TNF, lymphotoxin)Pasuporn Po‐ngernnakhttps://www.eseb2013.com/symposia5
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Page 9 and 10: 12/4/2012Multinucleated Giant Cells
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