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The “Toxicological” Safety Assessment Model(Based on the Review of Toxicological Data)• Lifetime-average, “high eaters only” EDI• HNEL from lifetime animal studies• Threshold behavior for toxic effects• Application of appropriate safety(uncertainty) factors (e.g., 10x and 10x)• Acceptable Daily Intake or ADI• Comparison of the EDI to the ADI• No effects at estimated consumption levels