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“Olestra”a macronutrient substitute for fat• Under the FD&C Act, olestra was a new foodadditive use…• 1987 Petition from P&G for olestra use as a fatsubstitute (later only for use in “savory snacks”)• …requiring FDA premarket safety evaluation.• This, in turn, required the review of data on likelyhuman exposure, toxicological properties and, as itturns out, effects on human physiology andnutrition, as well.