Download PDF - jifsan

More documents

Recommendations

Info

A Still More Complex “Circle” ofReasonable Certainty of No HarmHumanTolerance(physiologicaleffects; GI effects)Nutritional Effects(Nutrient Depletion andRestoration; gut microflora;metabolism effects, etc. )Identity & Exposure(Dose Response; Similarity toFood and normal bodily constituents)EDI/ADI(?)Allergenicity (FALCPA)Drug InterferenceEffectsPostmarketMonitoringActive/Passive
Relative Food-Related Concerns(A Popular View)• Added Food Chemicals• Environmental Contaminants in Food• Food Hazards of Natural Origin• Microbial Contamination of Food• Nutritional Hazards
Page 5 and 6:
A Core Statute for Food IngredientS
Page 7 and 8:
House of Representatives, Report No
Page 9 and 10:
REASONABLE CERTAINTY OF NO HARMLegi
Page 11 and 12:
Reasonable Certainty ofNo HarmWhat
Page 13 and 14: Traditional Safety Evaluation(Petit
Page 15 and 16: The “Toxicological” Safety Asse
Page 17 and 18: The “Circle” ofReasonable Certa
Page 19 and 20: “Olestra”a macronutrient substi
Page 21 and 22: Olestra: Molecular Structure
Page 28 and 29: Beyond “Toxicity” Studies• Fo
Page 30 and 31: Beyond “Toxicity” StudiesIn fac
Page 32 and 33: Summary of Olestra Data Review• I
Page 34 and 35: Summary of Olestra Data ReviewDrug
Page 36 and 37: Studies to Assess Nutritional Effec
Page 38 and 39: Summary of Olestra Data Review8-Wk
Page 40 and 41: Summary of Olestra Data ReviewStudi
Page 42 and 43: Carotenoids• Serum levels are aff
Page 44 and 45: GI Effects• After review by FDA o
Page 46 and 47: FDA’s s Safety Review: Summary•
Page 48 and 49: Labeling of FoodsContaining Olestra
Page 50 and 51: A More Complex “Circle” ofReaso
Page 52 and 53: “Generally Recognized as Safe”(
Page 54 and 55: GRAS Criteria: Comparing a GRASSubs
Page 56 and 57: 3 Types of Responseto a GRAS Notice
Page 58 and 59: Other Examples of “Bioactive”Fo
Page 60 and 61: Nutritional Risk Assessment?• For
Page 62 and 63: Nutritional Risk Assessment• An u
Page 66 and 67: Relative Food-Related Concerns(A Po
Page 68: The End!Thank You!
show all

Download PDF - jifsan

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?