Ranking Nucleophiles and Leaving Groups, Hammond's Postulate
Ranking Nucleophiles and Leaving Groups, Hammond's Postulate
Ranking Nucleophiles and Leaving Groups, Hammond's Postulate
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Comparing Nucleophile Quality withPotential Energy DiagramsLower electronegativitydestabilizes HS - .Some of this isresolved intransition state(but not all).E a (HS - )++EE a (Cl - )So, rate of attack by SH - isgreater than that of Cl - .reaction coordinate++The Hammond <strong>Postulate</strong>For similar reactions, differences in starting material orproduct stabilities will be reflected in transition state(to a lesser degree).+Difference instability here……is reflectedhere.++E+Wade 4-14reaction coordinate