Ranking Nucleophiles and Leaving Groups, Hammond's Postulate

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Inhibition of S N 2 by Neopentyl Groupsneopentyl bromide(primary, but stillhindered)

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What Makes a Good Leaving Group?3. Products are stable; S N 2 wouldn’t work much better inreverse.Example:+ +OH is a much better nucleophile than Br ;this reaction would revert if it ever happened.So it doesn’t happen.Steric Hindrance at the S N 2 Reaction CenterInhibits Reaction

Inhibition of S N 2 by Neopentyl Groupsneopentyl bromide(primary, but stillhindered)

Page 1 and 2: What Makes a Good Nucleophile?+ +1.
Page 3 and 4: Some Common NucleophilesComparing N
Page 5: What Makes a Good Leaving Group?1.

Ranking Nucleophiles and Leaving Groups, Hammond's Postulate

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