<strong>Traumatic</strong> <strong>Brain</strong> <strong>Injury</strong> (TBI) <strong>and</strong> <strong>Effects</strong> <strong>of</strong> <strong>Altitude</strong>:An Analysis <strong>of</strong> the Literatureespecially in the context <strong>of</strong> aeromedical evacuation that may require rapid ascent in unpressurizedaircraft. Clinical research to date emphasizes the need for efficient medical evacuation as well as earlymitigation <strong>of</strong> hypoxia, hypotension, ICP, dehydration <strong>and</strong> uncontrolled temperature abnormalities.Specifically, our review <strong>and</strong> analysis finds that:Exposure to very high altitudes can induce brain damage <strong>and</strong> impair cognitive functioning.Hypoxia, which is correlated with poor TBI outcome, likely plays a major role in altitude-relatedbrain injury.Elevated ICP <strong>and</strong> hypotension play an important role in determining outcome from brain injury.Fluid resuscitation <strong>and</strong> management is important to prevent hypotension <strong>and</strong> prevent adverseeffects <strong>of</strong> secondary brain injury <strong>and</strong>/or altitude exposure.Hyperthermia is a risk factor for secondary brain injury. Hyperthermia is common in post-acuteTBI, <strong>and</strong> can be the result <strong>of</strong> environmental high temperatures, strenuous physical activity,infection, or injury-related hypothalamic damage <strong>and</strong> impaired thermoregulation.Hypothermia has been linked to increased mortality in general trauma patients, including thosewith TBI. Hypothermia is a concern in military operational settings <strong>and</strong> in military aeromedicalevacuation, where the average interior temperature <strong>of</strong> a military cargo plane is around 59 °F.To reduce the risks associated with hyperthermia <strong>and</strong> hypothermia, it is important to assess <strong>and</strong>stabilize temperature in the pre-hospital setting.Retrospective clinical studies suggest that preventing hypoxia, controlling high ICP <strong>and</strong> temperaturestabilization are beneficial to TBI patient outcome. Therefore, it is important that TBI patients avoidexposure to hypoxia, hypotension, <strong>and</strong> extreme temperatures in the immediate aftermath <strong>of</strong> injury.Through this analysis, several key knowledge gaps are apparent. Primarily, there is a pressing need forclinical studies <strong>and</strong>/or case reports <strong>of</strong> military aeromedical evacuation <strong>and</strong> transport involving TBIcasualties. Virtually no research has yet been published to address the unique injury <strong>and</strong> treatmentexperiences <strong>of</strong> military TBI casualties in high-altitude settings. Clinical findings are crucial to inform thedevelopment <strong>of</strong> risk <strong>and</strong> injury pr<strong>of</strong>iles <strong>and</strong> protocols which can address timing <strong>and</strong> interventionsneeded to prevent adverse outcomes from exposure to altitude-related factors, as well as secondarybrain injury events. Specifically, additional research is needed to address the following concerns:Identify risks, benefits, intervention strategies <strong>and</strong> outcomes associated with militaryaeromedical transport <strong>of</strong> TBI casualtiesThis information is needed to identify the “ideal time to fly” <strong>and</strong> to inform risk pr<strong>of</strong>iles <strong>and</strong>injury protocols to address the timing <strong>and</strong> use <strong>of</strong> interventions to mitigate adverse effects <strong>of</strong>altitude <strong>and</strong>/or secondary brain injury events.Document the effects <strong>of</strong> altitude exposure on mild TBI (mTBI) <strong>and</strong> blast-induced neurotrauma(BINT)Although mTBI can involve structural neurological damage, little if any research to date hasaddressed the potential impact <strong>of</strong> secondary brain injury processes on mTBI. Most military TBIsare classified as mild, related to the effects <strong>of</strong> blast or explosion. The potential impact <strong>of</strong> altitudeon these injuries is largely unknown.September 14, 2010 2
<strong>Traumatic</strong> <strong>Brain</strong> <strong>Injury</strong> (TBI) <strong>and</strong> <strong>Effects</strong> <strong>of</strong> <strong>Altitude</strong>:An Analysis <strong>of</strong> the LiteratureDetermine what, if any, health risks or performance effects might occur among post-TBI/postconcussionmilitary personnel who return to duty at high altitudesOperational performance at altitude introduces physiologic stress, which may reveal lingeringfunctional post-TBI or repeated concussion-related deficits otherwise not clinically apparent atsea level. It is essential to determine how the return to duty in high-altitude <strong>and</strong> mountainousterrain might affect the health or performance <strong>of</strong> military personnel who are classified asrecovered from TBI.Investigate the efficacy <strong>of</strong> pharmacotherapeutic interventions for the prevention <strong>of</strong> altituderelated<strong>and</strong> secondary brain injuriesMedications effective in treating altitude illness can improve oxygenation <strong>and</strong> reduceinflammatory responses. To the extent that these processes also mediate secondary braininjury, altitude medications may be useful to mitigate effects <strong>of</strong> altitude <strong>and</strong> secondary injury onTBI outcome. Conversely, it is important to identify medications that are contraindicated for usein TBI at altitude.TBI is a persistent challenge in civilian <strong>and</strong> military settings, due to the inherent difficulties <strong>of</strong> preventingsecondary brain injury <strong>and</strong> controlling for environmental factors that may provoke or aggravatesecondary injury. Practical challenges are most pronounced in the combat casualty environment, wheremilitary medical practitioners are expected to deliver care in austere <strong>and</strong> sometimes hostileenvironments. This review hopes to inform these efforts, <strong>and</strong> to catalyze additional research as neededto determine optimal solution sets <strong>and</strong> treatment strategies.September 14, 2010 3