The Lerner Research Institute Notations - Cleveland Clinic Lerner ...

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RESEARCH DAYYoung Investigators ShineBasic Science, Clinical Research work honoredThe F. Merlin Bumpus JuniorInvestigator Awards in both BasicScience and Clinical Research were presentedduring the annual Lerner ResearchInstitute Research Day on Nov. 17, 2004.Paul DiCorleto, Ph.D., LRI Chair,presented the honors in the Basic Sciencecategory. Richard Rudick, M.D., Chair,Division of Clinical Research, bestowedthe recognition in the Clinical Researchclass.The following people were recognizedfor their work.Basic ScienceFirst Place:Laurent Chavatte,Ph.D., Cell Biology(sponsor: DonnaDriscoll, Ph.D., CellB i o l o g y ) ,“Mechanism ofselenoprotein biosynthesisin eukaryotes:Ribosomal protein L30 is a componentof UGA/selenocysteine recodingmachinery.”Second Place: Mark Whitmore,Ph.D., Cancer Biology (sponsor: BryanWilliams, Ph.D., Chair, Cancer Biology),“Synergistic activation of innate immunityby poly-IC and CPG DNA stimulatesenhanced antitumor activity against establishedB16-F10 pulmonary metastases.”Finalists: Mukesh Kumar Agarwal,Ph.D., Molecular Biology (sponsor:George Stark, Ph.D., F.R.S., MolecularBiology), “Placental transforming growthfactor beta protects p53-null ovarian cancercells from PALA-mediated death”;Hiroyuki Amano, M.D., Immunology(sponsor: Rob Fairchild, Ph.D.,Immunology), “Acute rejection of cardiacallografts in the absence of recipient CCR5is mediated by antibody”; and LisaMiddleton, Ph.D., Cell Biology (sponsor:Dr. Driscoll), “Translational recoding ofUGA as selenocysteine in selenoproteinsynthesis.”Neal Peachey, Ph.D., OphthalmicResearch, Cole Eye Institute, was Chair ofthe Basic Science Abstract SelectionCommittee.Clinical ResearchFirst Place: MichaelB. Davidson, D.O.,Internal Medicine(sponsor: DanielBrotman, M.D.,General InternalMedicine), “Diurnalblood pressure variationand triglyceride to HDL ratio inpatients without diabetes “Second Place: David Anthony, M.D.,Anesthesiology and Critical CareMedicine (sponsor: C. Allen Bashour,M.D., Anesthesia), “Serial changes in creatinineto predict postoperative hemodialysis,extended length of stay, and mortalityafter cardiac surgery.”Finalists: Joseph Abdelmalak, M.D.,Urology (sponsor: Raymond Rackley,M.D., Glickman Urological Insttute),“Botulinum A toxin (BOTOX) injectionfor the treatment of refractory overactivebladder”; Ratna Sajja, M.D., RadiationOncology (sponsor: John Suh, M.D., BrainTumor Institute), “Gamma knife radiosurgeryfor newly diagnosed and recurrentintracranial meningiomas”; and HuseyinNail Aydin, M.D., Colorectal Surgery(sponsor: Feza Remzi, M.D., ColorectalSurgery), “Evaluation of operative morbidityand mortality in diverticular disease -analysis of predictive risk factors and theirimpact on medical and surgical outcome.”Maria Siemionow, M.D., Ph.D.,Plastic Surgery, was the Chair of theClinical Research Abstract SelectionCommittee.Frederick W. Alt, Ph.D., Departmentof Genetics, Harvard University, was thekeynote speaker. His presentation wastitled “The Role of the DNA Double StrandBreak Response Recombination andSuppression of Oncogenic Translocationsand Amplification.” Research presentationswere given by Michael Kattan, Ph.D.,Chair, Department of Biostatistics andEpidemiology; Marina Antoch, Ph.D.,Cancer Biology; Riqiang Yan, Ph.D.,Neurosciences; and Roy Silverstein,M.D., Chair, Cell Biology.6 Notations · Winter 2005 The Lerner Research Institute
Genetics & Stem Cell Research BuildingResearchers start to move into new state-of-the-art facilityIt's a marriage of form and function.Work nears completion on TheLerner Research Institute's new Geneticsand Stem Cell Research Building -- astate-of-the-art facility that blends theopenness and aesthetics of the NA, NBand ND buildings with the functionalityand efficiency of the NC building.Laboratories will start to move in by theend of March.Paul Fox, Ph.D., Cell Biology, and amember of the Laboratory Design Team,said the team looked at the features of allthe LRI buildings and toured otherresearch facilities to see what works bestfor scientists. Among the team memberswere Paul DiCorleto, Ph.D., LRI Chair,Clemencia Colmenares, Ph.D., Directorof LRI Core Services, and Chris Kaczmar,Kaczmar Architects, which designed thebuilding’s interior.“The new building definitely picksthe best from the NC and the NB buildings,”said Dr. Fox.About 3-1/2 floors are almost readyfor use. The remaining space in the sixfloor,151,000-square-foot building willbe furnished as the LRI adds Staff.Among the new building’s features:• An open lab design that incorporatesas much natural light as possible,with flexible and efficientuse of lab space. Modular furnishingsallow easy reconfiguration ofresearch modules, including modularwalls and doors if desired.• Shared facilities for tissue culture,fume hoods, and glassware andequipment areas for efficient use ofspace.• Easy indoor access to the NC building(with ramps) and shared LRI facilities(such as wireless and wired Ethernetnetworks and the glass wash services).“We set out to design research spacethat maximizes bench, desk and storagespace,” Dr. Fox said. “We also wanted toreduce ambient noise, so we included labdividers and an acoustic tile ceiling. Wealso designated space for low-temp freezersoutside of the lab areas.”Research modules can be easily andquickly expanded or reduced according toresearch needs, and the entire layout ofthe research floors allows for easy collaborationamong Staff and researchers.There is a large classroom, conferencerooms, lunch break areas, darkrooms,and offices.Portions of two grants -- $10.9 millionfrom Ohio's Wright Capital Fund and$8.6 million from the state's BiomedicalResearch and Technology Transfer Fund-- were used for the $44 million buildingat East 96th Street and Cedar Avenue.Eventually it will house 500 people.The Ferchill Group, a Clevelandbasedreal estate development firm, brokeground in October 2003 and leases it toThe Cleveland Clinic.Eric Olson, Ph.D., one of the foremostauthorities on cardiovascular development,delivered the 20th Annual IrvineH. Page Lecture on October 6, 2004.Dr. Olson (right), Chairman of theDepartment of Molecular Biology atThe University of Texas SouthwesternMedical Center in Dallas, spoke ongene regulatory mechanisms that areresponsible for cardiac growth andhow they relate to common diseases,including heart failure. His lecture also touched on novel molecularstrategies being developed in his laboratory for modifying cardiacremodeling and function through changes in gene expression.Dr. Olson spent nearly two days atCCF meeting with Staff researchers,students and postdoctoral fellows atThe Lerner Research Institute. ThePage Lecture was sponsored by theDepartment of Cell Biology and hostedby its chair, Roy Silverstein, M.D.(left).The lecture series honors the memoryof Irvine H. Page, M.D., the first directorof the Division of Research (nowthe LRI). Dr. Page was a pioneer in hypertension research and astrong proponent of translational and basic research as critical componentsof the mission of the Clinic.The Lerner Research Institute Notations · Winter 2005 7
Page 2 and 3: NEUROSCIENCES$6.2 million multiple
Page 4 and 5: CELL BIOLOGYMacrophage inflammation
Page 8 and 9: An Inaugural EventFriends of theLER
Page 10 and 11: IMMUNOLOGYImproving the oddsFive-ye
Page 12: BIOMEDICAL ENGINEERINGCenter for Sp
Page 15 and 16: GRANTSGrants awarded for the second

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