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16:11:04 medications to the lower airway or I should16:11:06 actually say how does it compare to delivering16:11:09 medications to the lower airway in a child that's16:11:11 distressed, in other words, crying versus not16:11:14 crying, not distressed? This was looking at16:11:19 chromalin, which is an asthma medication back from16:11:21 the seventies and eighties which we really don't16:11:23 use anymore, because it's not a very good16:11:25 medication for asthma. P16:11:2816:11:28 Chromalin is absorbed across the respiratory16:11:30 epithelium and it undergoes hepatic and renal16:11:34 metabolism. They looked at the amount of16:11:36 chromalin in urine in 15 infants that were either16:11:39 distressed or not distressed. The not distressed16:11:43 infants excreted 0.43% of chromalin in their urine16:11:48 versus zero.11% in the distressed infants. And16:11:55 they are actually surprised with this finding.16:11:56 They stated in the last sentence before their16:11:58 methods section, "We expected that with larger16:12:01 title volumes, we would have better delivery of16:12:04 drug in crying infants, but the opposite was16:12:07 true."16:12:0816:12:08 It makes sense when we think that have video clip16:12:10 that we just looked at. Children, when they're16:12:13 crying, they're not spending very much time in