View the Transcript.

16:29:07 And after they sifted through hundreds of studies,16:29:10 there were six that fit these criteria. They16:29:13 looked at what was better. The primary outcome16:29:17 was discharge from the emergency department. The16:29:20 line in the middle with one is neutral. If you're16:29:23 to the left of that, it favors metered dose16:29:26 inhaler with valved holding chamber. If you're to16:29:29 the right of that, it favors nebulizer. They16:29:32 found when they did this meta‐analysis that16:29:34 metered dose inhalers with valved holding chambers16:29:36 was superior. It decreased admissions from the16:29:40 emergency department by 50%. They also looked at16:29:43 secondary indicators, such as clinical scores.16:29:46 That was improved, also. 1816:29:4816:29:51 This is another large meta‐analysis in which16:29:54 randomized control trials were looked at, and they16:29:58 divided this into different categories. Delivery16:30:01 of short acting beta agonists in the emergency16:30:03 department, nebulizers, and metered dose inhalers16:30:06 with spacers are equally effective. Delivery of16:30:09 short acting beta agonists in the hospital16:30:11 setting. No difference in pulmonary function16:30:13 response between nebulizers and MDI with spacers.16:30:17 And the outpatient setting, no difference between16:30:20 MDI and dry powder inhalers. They said the use of16:30:23 nebulizers has not been adequately studied in