Major Subsidiaries and Affiliates - Takeda

Major Subsidiaries and Affiliates15314 4 17 216 95 6 1110813121743211214 3 651257 6Takeda PharmaceuticalCompany Limited10 918Europe[Pharmaceuticals]123456Takeda Europe Holdings B.V.Voting Shares Owned: 100%Takeda Pharmaceuticals Europe LimitedVoting Shares Owned: 100%3Takeda Cambridge LimitedVoting Shares Owned: 100%3Takeda Global Research & DevelopmentCentre (Europe) Ltd.Voting Shares Owned: 100%3Laboratoires TakedaVoting Shares Owned: 100%3IDM Pharma, S.A.S.Voting Shares Owned: 100%6789Takeda UK LimitedVoting Shares Owned: 100%3Takeda Italia Farmaceutici S.p.A.Voting Shares Owned: 76.9%3Takeda Pharma GmbHVoting Shares Owned: 100%310 Takeda Pharma Ges.m.b.H.Voting Shares Owned: 100%411 Takeda Pharma AGVoting Shares Owned: 100%412 Takeda Farmacéutica Espãna S.A.Voting Shares Owned: 100%313 Takeda FarmacêuticosPortugal, Unipessoal LDAVoting Shares Owned: 100%314 Takeda Ireland LimitedVoting Shares Owned: 100%15 Takeda PharmaceuticalsNordics ABVoting Shares Owned: 100%316 Takeda PharmaceuticalsBenelux BVBAVoting Shares Owned: 100%317 Takeda İlaçları TicaretLimited ŞirketiVoting Shares Owned: 100%3104 Takeda Annual Report 2011 For locations and current contact information, please see Takeda’s websitehttp://www.takeda.com/about-takeda/global-operations/index_50.html

Japan[Pharmaceuticals]123Nihon Pharmaceutical Co., Ltd.Voting Shares Owned: 87.5%Takeda Healthcare ProductsCo., Ltd.Voting Shares Owned: 100%Takeda Bio DevelopmentCenter LimitedVoting Shares Owned: 100%[Others]56Wako Pure ChemicalIndustries, Ltd.Voting Shares Owned: 70.3%Mizusawa IndustrialChemicals, Ltd.Voting Shares Owned: 54.2%423865719Americas4Amato PharmaceuticalProducts, Ltd.Voting Shares Owned: 30%[Pharmaceuticals]101Takeda America Holdings, Inc.Voting Shares Owned: 100%2Takeda Ventures, Inc.Voting Shares Owned: 100%13Takeda San Diego, Inc.Voting Shares Owned: 100%1114Takeda San Francisco, Inc.Voting Shares Owned: 100%1Asia[Pharmaceuticals]567Takeda Pharmaceuticals International, Inc.Voting Shares Owned: 100%1Takeda Pharmaceuticals North America, Inc.Voting Shares Owned: 100%1Takeda Canada, Inc.Voting Shares Owned: 100%1Management Organization1Takeda Pharmaceuticals AsiaPrivate LimitedVoting Shares Owned: 100%7Takeda (Thailand), Ltd.Voting Shares Owned: 52%8Takeda Global Research & Development Center, Inc.Voting Shares Owned: 100%22Takeda (China) Holdings Co., Ltd.Voting Shares Owned: 100%8P.T. Takeda IndonesiaVoting Shares Owned: 70%9Millennium Pharmaceuticals, Inc.Voting Shares Owned: 100%134Takeda Pharmaceutical (China)Company LimitedVoting Shares Owned: 100%7Tianjin TakedaPharmaceuticals Co., Ltd.Voting Shares Owned: 100%9Takeda Global Research& Development Center(Asia) Pte. Ltd.Voting Shares Owned: 100%10 Takeda Singapore PteLimitedVoting Shares Owned: 100%51011Takeda Pharmaceuticals Mexico, S.A. de C.V.Voting Shares Owned: 100%Takeda Farmacêutica Brasil LTDAVoting Shares Owned: 100%Holding Company, etc. Research DevelopmentManufacturingMarketing56Takeda Pharmaceuticals Taiwan,Ltd.Voting Shares Owned: 100%Takeda Pharmaceuticals(Philippines), Inc.Voting Shares Owned: 50%11 Takeda PharmaceuticalsKorea Co., Ltd.Voting Shares Owned: 100%12 Takeda PharmaceuticalsIndia Private LimitedVoting Shares Owned: 100%1Owned by Takeda America Holdings, Inc.2100% subsidiary of Takeda Pharmaceuticals North America, Inc.3Owned by Takeda Europe Holdings B.V.4100% subsidiary of Takeda Pharma GmbH5100% subsidiary of Takeda Cambridge Limited6100% subsidiary of Laboratoires Takeda7Owned by Takeda (China) Holdings Co., Ltd.Takeda Annual Report 2011105