MMI Clinical and Translational Research Scholars Programme ...
MMI Clinical and Translational Research Scholars Programme ...
MMI Clinical and Translational Research Scholars Programme ...
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Dr Fabio QuondamatteoProf Lokesh JoshiDr Karl McCullaghDr Francis FinucaneProf Rob WoodsProf Richard FlavinDr Howard FearnheadDr Thomas KropmansProf Peter DockeryDr John LynchDr Faisal SharifProf Corrado SantocanaleDr Mary MurphyDr Leo KevinDr Paul DonnellanProf John MorrisonProf Frank GilesDr Malini OlivoDr Mark da CostaStudy of the cell biological role of basement membrane <strong>and</strong> extracellular matrix componentsin vivo; Glycoscience; Cell biological aspects of normal <strong>and</strong> pathological development; <strong>Clinical</strong>Anatomy; development of therapeutic devices for neuromuscular stimulations.Glycosciences <strong>and</strong> Bioengineering to discover <strong>and</strong> develop novel molecules, processes<strong>and</strong> biomaterials <strong>and</strong> relevant technologies for biotherapeutic <strong>and</strong> biodiagnostic purposes;Post-translational modifications <strong>and</strong> recombinant protein engineering; protein <strong>and</strong> peptidetherapeutics; glycosensors, glycosignatures, <strong>and</strong> glycomimetics.Muscular Dystrophy; Proteins associated with the dystrophin protein complex; Cell signalling<strong>and</strong> regulation of skeletal muscle fibre types; Growth <strong>and</strong> regeneration of muscle.Endocrinology; Obesity; Bariatric Medicine; Diabetes.Relationships between the conformations of carbohydrate molecules <strong>and</strong> biologicalrecognition <strong>and</strong> activity, particularly the mechanisms involved in carbohydrate recognitionin immunological events; computational techniques of molecular dynamics <strong>and</strong> free energyperturbation simulations; examinations of bacterial antigen-antibody interactions, as well ascarbohydrate-lectin interactions.Molecular mechanisms of breast cancer; breast cancer progression <strong>and</strong> heterogeneity;evaluation of different stages of the disease from early precursor lesions through in situtumours to invasive disease <strong>and</strong> metastasis.Biochemical <strong>and</strong> molecular basis of apoptotic cell death; Neurological Disorders, CardiovascularDisease, <strong>and</strong> Cancer with the aim of developing new therapies for these diseases.Postgraduate medical education <strong>and</strong> continuing professional development; application ofinformation <strong>and</strong> communication technologies to support evidence practice in both hospital<strong>and</strong> community based health care.Neurobiology; Cellular interactions in the developing <strong>and</strong> ageing nervous system; Development<strong>and</strong> repair of the Spinal Cord; Human Reproduction; Structure-Function of the HumanEndometrium; Cellular effects of endocrine disrupting chemicals on reproductive tissues;Feto-maternal interface.Genetics of epilepsy predisposition; pharmacogenetics of anti-epileptic drug response;genetics of Parkinson’s disease; psychosocial impact of epilepsy.Vascular biology <strong>and</strong> Gene Eluting Stents; translational medicine focusing on cardiovascularclinical trials for medical devices <strong>and</strong> basic science outputs; myocardial regeneration.DNA replication <strong>and</strong> cell cycle progression; developing novel therapeutic strategies <strong>and</strong>molecular biomarkers to follow drug action in cancer patients; molecular characterization ofCdc7 kinase <strong>and</strong> of its substrates <strong>and</strong> defining the mechanism of action of emerging Cdc7inhibitors.Adult stem cells for tissue regeneration in cartilage repair <strong>and</strong> osteoarthritis; Biology of vascularderived stem cells in atherosclerosis; Cardiomyogenic differentiation of adult stem cells; Effectof electroactive particles.Effects of sepsis on myocardial performance <strong>and</strong> on mitochondrial bioenergetics, volatileanaesthetic agents <strong>and</strong> sidlenafil in the Foeto-Placental Circulation.Medical Oncology; Extensive-Stage Small Cell Lung Cancer; <strong>Clinical</strong> Trials; national breastcancer trials; radiation oncology.Myometrial physiology; Pre-term labour; Pre-natal diagnosis <strong>and</strong> high-risk obstetrics; volatileanaesthetic agents in the Foeto-Placental Circulation.<strong>Clinical</strong> <strong>Research</strong>; therapy for patients suffering from treatment-resistant or refractory cancer;development of novel drugs, immunotherapies, <strong>and</strong> other highly targeted approaches,including cancer-directed viruses.Molecular Imaging <strong>and</strong> Photomedicine; nano-biophotonics science for biomedical diagnostics<strong>and</strong> therapeutics; early detection of cancer using novel minimally invasive endoscopic opticaltechniques <strong>and</strong> for the treatment of cancer using light activation of drugs that target cancer.Cardiothoracic Surgery.8
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