Microbial Diseases of the Cardiovascular and Lymphatic Systems
Microbial Diseases of the Cardiovascular and Lymphatic Systems
Microbial Diseases of the Cardiovascular and Lymphatic Systems
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Infectious Mononucleosis• “Kissing disease” – caused by Epstein-Barr virus(EBV) <strong>of</strong> Herpesviridae, also known as HHV-4• Well-established relationship between HHV-4 <strong>and</strong>oncogenesis (Burkitt’s Lymphoma etc.)• Virus multiplies in parotid gl<strong>and</strong>s <strong>and</strong> is present insaliva. It causes <strong>the</strong> proliferation <strong>of</strong> atypicallymphocytes (life-long infection) – Transmission viasaliva• Most people (~95%) infected. Childhood infectionusually asymptomatic. Adolescent infection Mononucleosis.• Characteristic triad: fever, pharyngitis, <strong>and</strong>lymphadenopathy (+spleno- <strong>and</strong> hepatomegaly)lasting for 1 to 4 weeks.Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings
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