Microbial Diseases of the Cardiovascular and Lymphatic Systems
Microbial Diseases of the Cardiovascular and Lymphatic Systems
Microbial Diseases of the Cardiovascular and Lymphatic Systems
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• Proliferation <strong>of</strong> infected B cells results in massiveactivation <strong>and</strong> proliferation <strong>of</strong> T c cells (CD8 cells) characteristic lymphoid hyperplasia.• Transformation <strong>of</strong> B cells to immortal plasmacytoidcells secrete a wide variety <strong>of</strong> IgMs = heterophileantibodies (Monospot test)• Commercially-available test kits are 70-92% sensitive<strong>and</strong> 96-100% specific"Downy cell“: lymphocytes infectedby EBV or CMV in infectiousmononucleosis. Cytoplasmic rim isintensely blue <strong>and</strong> has tendency to"stream" around adjacent red cells.
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