Managing <strong>patients</strong> <strong>with</strong> <strong>palpitations</strong> 931Table 10 General recommendations for <strong>the</strong> treatment<strong>of</strong> <strong>palpitations</strong>Therapy should be directed towards <strong>the</strong> aetiological cause.Patients should be reassured in case <strong>of</strong> a benign cause.Use <strong>of</strong> adrenergic substances such as caffeine or alcohol-containingbeverages should be restrained.Good control <strong>of</strong> cardiovascular risk factors, specifically <strong>of</strong>hypertension, should be ensured.If <strong>the</strong>re is a recent stressful life-event, psychiatric counselling may be <strong>of</strong>help.In <strong>patients</strong> <strong>with</strong> symptoms <strong>of</strong> anxiety and depression, a specific <strong>the</strong>rapyis warranted.If a specific arrhythmia is found, <strong>the</strong> appropriate <strong>the</strong>rapy may beantiarrhythmic drugs, ablation, or even an implantable defibrillator.In <strong>the</strong> case that arrhythmias are found to be related to systemicdiseases or to <strong>the</strong> use <strong>of</strong> pro-arrhythmic drugs, <strong>the</strong>rapy, <strong>of</strong> course,must aim to remove <strong>the</strong> underlying conditions.Table 11 Criteria for <strong>the</strong> hospitalization <strong>of</strong> <strong>patients</strong><strong>with</strong> <strong>palpitations</strong>Diagnostic purposesSevere structural heart disease, suspected or ascertainedPrimary electrical heart disease, suspected or ascertainedFamily history <strong>of</strong> sudden deathNeed to perform EPS, invasive investigations or in-hospitaltelemetric monitoringTherapeutic purposesBradyarrhythmias requiring implantation <strong>of</strong> pacemakerPacemaker/ICD malfunction not rectifiable by reprogrammingVentricular tachyarrhythmias requiring immediate interruption and/or ICD implantation or ca<strong>the</strong>ter ablationSupraventricular tachycardias requiring interruption immediately orin a short time, or ca<strong>the</strong>ter ablationPresence <strong>of</strong> heart failure or o<strong>the</strong>r symptoms <strong>of</strong> haemodynamiccompromiseSevere structural heart diseases requiring surgery or interventionalproceduresSevere systemic causesSevere psychotic decompensationClearly, <strong>patients</strong> <strong>with</strong> <strong>palpitations</strong> will benefit <strong>from</strong> <strong>the</strong> samepreventive measures recommended to <strong>the</strong> general populationand to <strong>patients</strong> <strong>with</strong> cardiovascular disease. 93 Especially in <strong>patients</strong><strong>with</strong> ventricular ectopy 94 and possibly also in <strong>patients</strong> <strong>with</strong> atrialectopic beats 95 , although scientific evidence is lacking, intensifiedreduction <strong>of</strong> cardiovascular risk factors may be warranted. Thismay comprise, among o<strong>the</strong>rs, smoking cessation, <strong>the</strong>rapy <strong>of</strong> dyslipidemia,management <strong>of</strong> hypertension, heart failure, and diabetesmellitus, to name but a few. Moderate exercise is a healthy habitthat helps in controlling cardiovascular risk factors. On <strong>the</strong> o<strong>the</strong>rhand, high-intensity endurance sport practice has been related toan increased risk <strong>of</strong> atrial fibrillation. 96It is beyond <strong>the</strong> scope <strong>of</strong> this <strong>paper</strong> to discuss in depth <strong>the</strong>specific <strong>the</strong>rapy in all arrhythmic conditions causing <strong>palpitations</strong>.In this regard, we refer <strong>the</strong> readers to current guidelines. 16,17 In<strong>the</strong> case that arrhythmias are found to be related to systemic diseasesor to <strong>the</strong> use <strong>of</strong> pro-arrhythmic drugs, <strong>the</strong>rapy, <strong>of</strong> course,must aim to remove <strong>the</strong> underlying conditions. The general recommendationsfor <strong>the</strong> treatment <strong>of</strong> <strong>palpitations</strong> are listed inTable 10.When to hospitalize <strong>the</strong> patientDiagnostic purposesThe vast majority <strong>of</strong> <strong>patients</strong> <strong>with</strong> <strong>palpitations</strong> can be assessed in anoutpatient setting. Indeed, most <strong>of</strong> <strong>the</strong> investigations required for<strong>the</strong> diagnostic evaluation <strong>of</strong> <strong>patients</strong> <strong>with</strong> <strong>palpitations</strong> can becarried out in an ambulatory or day-hospital setting. In <strong>the</strong> studyby Weber and Kapoor, 47 an EPS and a haemodynamic studywere performed in only 5% <strong>of</strong> <strong>patients</strong>.However, depending on <strong>the</strong> availability <strong>of</strong> outpatient ECG monitoringdevices, hospitalization may be considered for <strong>patients</strong> <strong>with</strong>very frequent symptoms, when short-term bed-side monitoring islikely to reveal <strong>the</strong> underlying diagnosis. Moreover, <strong>patients</strong> <strong>with</strong><strong>palpitations</strong> should also be hospitalized when <strong>the</strong> initial clinicalevaluation suggests an imminent risk for serious arrhythmias(Table 11). For example, <strong>patients</strong> <strong>with</strong> primary electrical heartdiseases should be carefully evaluated when presenting <strong>with</strong>97 – 116<strong>palpitations</strong>.Therapeutic purposesThe criteria for <strong>the</strong> hospitalization <strong>of</strong> <strong>patients</strong> <strong>with</strong> <strong>palpitations</strong> for<strong>the</strong>rapeutic purposes are reported in Table 11. Generally, <strong>patients</strong><strong>with</strong> cardiac arrhythmias and/or structural heart disease will needemergency hospitalization when <strong>the</strong>y complain <strong>of</strong> <strong>palpitations</strong>associated <strong>with</strong> haemodynamic compromise, chest pain, orsyncope, as well as if implantation or revision <strong>of</strong> implanted117 – 121devices is indicated.Conflicts <strong>of</strong> interest: A.R. is a consultant for san<strong>of</strong>i-aventis,Boehringer-Ingheleim, Biosense Webster, and St Jude Medical,and has received honoraria <strong>from</strong> san<strong>of</strong>i-aventis, Boehringer Ingheleim,and Medtronic. L.M. has received honoraria or consulting fees<strong>from</strong> Bard, Biosense Webster, Medtronic, Boston Scientific, St JudeMedical, San<strong>of</strong>i Aventis, Biotronik, and Sorin Group, and hasreceived research grants <strong>from</strong> Biosense Webster, Medtronic,Boston Scientific, and St Jude Medical. C.B.-L. has received researchgrants <strong>from</strong> Octopus, AtriCure, and Medtronic. M.J.P.R. is a consultantor advisory-board member for Biosense Webster, BoehringerIngelheim, St Jude Medical, and Stereotaxis. J.M.M. is aconsultant to Medtronic, has received honoraria <strong>from</strong> BostonScientific and St Jude Medical, and has had research support<strong>from</strong> all three companies.References1. Mayou R. Chest pain, <strong>palpitations</strong> and panic. J Psychosom Res 1998;44:53–70.2. Messineo FC. Ventricular ectopic activity: prevalence and risk. 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