Issue 10, pp. 753-832, October 1861, SMSJ

778 Joseph Jones, on the Indigenous [October,cent, cut short,) than in those first submitted to the action ofarsenic, (40 per cent, only cut short.)The general conclusion lie draws is, that the sulphate ofquinine is not replaceable by arsenic ; and especially is thistrue in respect to the fevers of hot climates, where it is neesary to apportion the dose to the intensity of the malady ;under the latter circumstances, we are immediately arrestedin the arsenical treatment by the fear of poisoning.In thosecountries where, from one paroxysm to another, the pyreniamay become more severe, remittent and pernicious, arsenicshould not be employed during the endemo-epidemic season.Confirmation of Results by other Observers.—After mentioningMM. Mayer, Cordier, Pasquier and Gouge, as arriving atsimilar conclusions to his own, he states that in the Pontinemarshes, Dr. Minzi, physician to the Central hospital of thatcountry, has experimented with arsenic in more than 400cases, giving it to the extent of three centigrammes a day, andat last abandoning it from want of success. M. SalvagnoliMarchetti also, out of ID cases, found 15 resisting arsenic.Arsenic in Inveterate Cases and inMarsh Cachexia.—Theobservations of M. Jacqnot do not encourage recourse to arsenicin inveterate fevers ;and M. Cordier also concludes fromhis experience in Algeria, that it is the more recent andslighter cases which yield most readily to arsenic. In thepalustrial cachexia he thinks that arsenic may perhaps be usedas an alterative, but that it is incapable of replacing iron andother tonics, which it is necessary to conjoin with it.IZelajiscs.—In preventing relapses, arsenic is inferior to sulphateof quinine. Out of 72 cases treated with arsenic, therelapses w r ere 22 or 20 percent.—certainly a large proportion.They were less frequent in the cases treated with quinine.The relapses occurred even during the period of administrationof the arsenic, which was continued after the cessation ofthe fever.This was not observed in the instances of the quininetreatment.