World Health Organization Classification of Tumours Pathology and ...

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TP53 tumour suppressor gene in 27% ofthe chromophobe RCCs. Sükösd et al.{2531} demonstrated loss of heterozygosity(LOH) around the PTEN gene atthe 10q23.3 chromosomal region.Prognosis and predictive factorsSarcomatoid phenotype is associatedwith aggressive tumour growth and thedevelopment of metastasis.AFig. 1.37 Chromophobe renal cell carcinoma. A Electron micrograph showing the numerous cytoplasmicmicrovesicles and thick cytoplasmic membranes. B The perinuclear rarefaction and peripheral condensationof mitochondria responsible for the perinuclear halos.BFig. 1.38 Chromophobe renal cell carcinoma. Survival curves by grade for patients with chromophobe renalcell carcinoma. From C.M. Lohse et al. {1532}.32 Tumours of the kidney
Carcinoma of the collectingducts of BelliniJ.R. SrigleyH. MochDefinitionA malignant epithelial tumour thought tobe derived from the principal cells of thecollecting duct of Bellini.ICD-O code 8319/3SynonymCollecting duct carcinoma, Bellini ductcarcinoma.EpidemiologyCollecting duct carcinoma is rare,accounting for
Page 1 and 2: World Health Organization Classific
Page 3 and 4: This volume was produced in collabo
Page 5 and 6: Contents1 Tumours of the kidney 9WH
Page 7 and 8: CHAPTER 1Tumours of the KidneyCance
Page 9 and 10: TNM classification of renal cell ca
Page 11 and 12: one quarter of kidney cancers in bo
Page 13 and 14: Familial renal cell carcinomaM.J. M
Page 15 and 16: Table 1.02Genotype - phenotype corr
Page 17 and 18: ABFig. 1.11 A Multiple cutaneous le
Page 21 and 22: Clear cell renal cell carcinomaD.J.
Page 23 and 24: Fig. 1.20 Clear cell renal cell car
Page 25 and 26: Papillary renal cell carcinomaB. De
Page 27 and 28: ABFig. 1.29 Papillary renal cell ca
Page 29: Fig. 1.33 Chromophobe RCC with sarc
Page 33 and 34: Renal medullary carcinomaC.J. Davis
Page 35 and 36: Renal carcinomas associated withXp1
Page 37 and 38: Renal cell carcinoma associated wit
Page 39 and 40: Papillary adenoma of the kidneyJ.N.
Page 41 and 42: of this tumour. Microscopic extensi
Page 43 and 44: ABFig. 1.59 Metanephric adenoma. A
Page 45 and 46: esults in intratumoral aneurysms. O
Page 47 and 48: peritumoural fibrous pseudocapsule.
Page 49 and 50: increases in prevalence to approxim
Page 51 and 52: Nephrogenic rests andnephroblastoma
Page 53 and 54: Cystic partially differentiatedneph
Page 55 and 56: ABFig. 1.80 Clear cell sarcoma of t
Page 57 and 58: ABFig. 1.85 Rhabdoid tumour of the
Page 59 and 60: transcription factor is fused to th
Page 61 and 62: LeiomyosarcomaS.M. BonsibDefinition
Page 63 and 64: AngiomyolipomaG. MartignoniM.B. Ami
Page 65 and 66: melanocytic and smooth muscle marke
Page 67 and 68: Multinucleated and enlarged ganglio
Page 69 and 70: HaemangiomaP. TamboliDefinitionHaem
Page 71 and 72: Fig. 1.107 Juxtaglomerular cell tum
Page 73 and 74: Intrarenal schwannomaI. Alvarado-Ca
Page 75 and 76: Mixed epithelial and stromal tumour
Page 77 and 78: Synovial sarcoma of the kidneyJ.Y.
Page 79 and 80: Renal carcinoid tumourL.R. BéginDe
Page 81 and 82:
Primitive neuroectodermal tumour(Ew
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Paraganglioma / PhaeochromocytomaPh
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LeukaemiaA. OraziInterstitial infil
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WHO histological classification of
Page 89 and 90:
TNM classification of carcinomas of
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The risk of bladder cancer goes dow
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Tumour spread and stagingUrinary bl
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feature in such patients undergoing
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AFig. 2.12 Infiltrative urothelial
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AFig. 2.15 A Infiltrating urothelia
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it difficult to identify genes lead
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Alterations of 9p21 and p15/p16 bel
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nostic role in invasively growing b
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Urothelial hyperplasiaJ.I. EpsteinU
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Urothelial papillomaC. BuschS.L. Jo
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Somatic geneticsUltrastructure, ant
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In spite of the overall orderly app
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Urothelial carcinoma in situI.A. Se
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aberrations, often including high l
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grade carcinomas recur frequently (
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AFig. 2.47 Squamous cell carcinoma.
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grading to be a significant morphol
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AFig. 2.57 Adenocarcinoma. A High p
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Urachal carcinomaA.G. AyalaP. Tambo
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Clear cell adenocarcinomaE. OlivaDe
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Small cell carcinomaF. AlgabaG. Sau
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mon in females by 1.4:1 {1845}. The
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RhabdomyosarcomaI. LeuschnerDefinit
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AngiosarcomaJ. ChevilleDefinitionAn
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Malignant fibrous histiocytomaJ. Ch
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Granular cell tumourI.A. Sesterhenn
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LymphomasA. MarxDefinitionMalignant
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ABCFig. 2.87 Metastatic tumours to
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makes 4.6% of lower urinary tracttu
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and patients with pT 2 tumours have
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Table 2.07Anatomic classification o
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prominent basal epithelial cell lay
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WHO histological classification of
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Acinar adenocarcinomaJ.I. EpsteinF.
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have been seen in high-risk countri
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ABCFig. 3.07 A Pelvic metastases of
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expression of PSMA in serum of both
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AFig. 3.12 A Organ-confined adenoca
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glands. These are perineural invasi
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have occasional p63 immunoreactive
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ABFig. 3.25 A Pseudohyperplastic ad
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PSA positive. Associated acinar ade
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AAFig. 3.36 Schematic diagram of th
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AFig. 3.39 A Gleason score 3+3=6. B
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and prostatectomy Gleason score{375
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Table 3.01Prostate cancer susceptib
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AFig. 3.52 A Immunohistochemistry f
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ABFig. 3.57 A Pathological stage an
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Fig. 3.59 Preoperative PSA levels (
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ABFig. 3.61 A Flat and tufting patt
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ABFig. 3.65 High grade PIN with foa
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Table 3.04Risk of subsequent carcin
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sue. Transrectal needle core biopsi
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Urothelial carcinomaD.J. GrignonDef
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CK20 in the majority of cases and h
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Basal cell carcinomaP.H. TanA. Bill
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ABFig. 3.84 Small cell carcinoma. A
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ABFig. 3.87 A Malignant phyllodes t
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Haematolymphoid tumoursK.A. Iczkows
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gliomas should not be designated as
Page 212 and 213:
CHAPTER 4XTumours of the of the Tes
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TNM classification of germ cell tum
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Germ cell tumoursP.J. WoodwardA. He
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senting symptom: back or abdominalp
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ABFig. 4.03 Germ cell tumours genet
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process at all {1524}. In addition,
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ABFig. 4.12 Comparison of morpholog
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small tumour insufficient to produc
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ABCFig. 4.22 Seminoma. A Pseudoglan
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ABFig. 4.27 Spermatocytic seminoma.
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Differential diagnosesDifferential
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Histologic patternsMicrocystic or r
Page 236 and 237:
AFig. 4.40 Yolk sac tumour. A Pleom
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TeratomaTeratomas are generally wel
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ABCFig. 4.49 Teratoma. A Teratoma w
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ABFig. 4.52 Teratoma with somatic t
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ABFig. 4.59 Mixed germ cell tumours
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ABCFig. 4.64 Leydig cell tumour. A
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AFig. 4.69 Androgen insensitivity s
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tinguished from Sertoli cell nodule
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ound and have spherical, regularly
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Tumours containing both germ cell a
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Miscellaneous tumours of the testis
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Lymphoma and plasmacytoma of thetes
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Tumours of collecting ducts and ret
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Tumours of paratesticular structure
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EpidemiologyNodular mesothelial hyp
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ABFig. 4.104 Papillary cystadenoma
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Fig. 4.109 Desmoplastic small round
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Fig. 4.115 Leiomyosarcoma. Coronal,
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Secondary tumoursC.J. DavisDefiniti
Page 274 and 275:
CHAPTER 5Tumours of the PenisThe in
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Malignant epithelial tumoursA.L. Cu
Page 278 and 279:
ABFig. 5.05 A Well differentiated s
Page 280 and 281:
ABFig. 5.10 Squamous cell carcinoma
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Fig. 5.17 Low grade papillary carci
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5 cm in diameter. The term has been
Page 286 and 287:
Melanocytic lesionsA.G. AyalaP. Tam
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Fig. 5.29 Lobular capillary haemang
Page 290 and 291:
ABFig. 5.34 A Kaposi sarcoma of the
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LymphomasA. MarxDefinitionPrimary p
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ContributorsDr Lauri A. AALTONENRes
Page 296 and 297:
Dr Kyu Rae KIMDepartment of Patholo
Page 298 and 299:
Dr Thomas M. ULBRIGHT*Department of
Page 300 and 301:
3.03.01 Dr D.M. Parkin03.02 WHO/NCH
Page 303 and 304:
115. Ariel I, Sughayer M, Fellig Y,
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246. Birt AR, Hogg GR, Dube WJ (197
Page 307 and 308:
374. Cardone G, Malventi M, Roffi M
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502. Corti B, Carella R, Gabusi E,
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633. Donhuijsen K, Schmidt U, Richt
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768. Fischer J, Palmedo G, von Knob
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900. Goedert JJ, Cote TR, Virgo P,
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1028. Hartmann A, Dietmaier W, Hofs
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1162. Iezzoni JC, Fechner RE, Wong
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1293. Keetch DW, Catalona WJ (1995)
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1424. Ladanyi M, Lui MY, Antonescu
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1548. Lopez-Beltran A, Croghan GA,C
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1681. McLaughlin JK, Silverman DT,
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1816. Moudouni SM, En-Nia I, Rioux-
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1945. Ohori M, Wheeler TM, Kattan M
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2070. Phillips G, Kumari-Subaiya S,
Page 335 and 336:
2199. Riou G, Barrois M, Prost S, T
Page 337 and 338:
2327. Schmidt L, Junker K, Weirich
Page 339 and 340:
2450. Smith G, Elton RA, Beynon LL,
Page 341 and 342:
2572. Tamboli P, Mohsin SK, Hailema
Page 343 and 344:
2693. van Echten J, Timmer A, van d
Page 345 and 346:
2816. Wick MR, Berg LC, Hertz MI (1
Page 347 and 348:
2937. Zhuang Z, Park WS, Pack S, Sc
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CCNB, 226CCND1, 105, 108CCND2, 226,
Page 351 and 352:
JJuvenile type granulosa cell tumou
Page 353 and 354:
Promoter methylation, 21Prostate sp
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