Psychological Support and Mgmt of ICU Psychosis
Psychological Support and Mgmt of ICU Psychosis
Psychological Support and Mgmt of ICU Psychosis
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Mood Stabilizer: Divalproex• RCT in nursing home 1• 6-week placebo vs. individual dose (mean serum level 45mcg/ml)• 56 subjects with dementia; 6 subjects discontinued treatment• Medically trail population• Results : trends for decreased scores on measures <strong>of</strong> agitation<strong>and</strong> psychosis, also on CGI ratings• Did not reach level <strong>of</strong> statistical significance• Sujects with higher baseline MMSE more likely to improve• Tolerability: Sedation, gastrointestinal symptoms, fallcommon• 6-week open-label extension 2• Sedaiton <strong>and</strong> falls continued to be most common side effects1. Porsteinsson AP, et al. Am J Geriatr Psychiatry. 2001;9:58-66.2. Porsteinsson AP, et al. Am J Geriatr Psychiatry. 2003;11:434-440.
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