Psychological Support and Mgmt of ICU Psychosis

Vascular depression hypothesisPremises• Vascular disorders are associated withdepression• Hyperintensities on MRI areassociated with vascular disorder• Subcortical disease is associated withdepression• Late-onset depression is associatedwith greater vascular disease andvascular risk• Late-onset depression is associatedwith more deep white matterabnormality than early-onsetdepression in later lifeProposed features• Mainly late-onset• Reduced depressive ideation• Reduced insight• More overall morbidity• Apathy and retardation• More cognitive impairment(particularly executivedysfunction)• Poorer recovery