- Page 1 and 2: Advances in the stereoselectivesynt
- Page 3: ACKNOWLEDGMENT:I would like to than
- Page 6 and 7: Summary:Numerous drugs are chiral,
- Page 8 and 9: IndexII2.2 Synthesis of enantiopure
- Page 10 and 11: IndexIV4.4. Stereochemical Assignme
- Page 12 and 13: IndexVImethyl amine 69 1446.6. Stud
- Page 14 and 15: IndexVIII8.23.3.1 Desilylation usin
- Page 16 and 17: Chapter 1 11.Introduction1.1. Chira
- Page 18 and 19: Chapter 1 3The concept of stereoche
- Page 20 and 21: Chapter 1 5switches is in the area
- Page 24 and 25: Chapter 1 914CH 3Cyt P-450 DMOH3O 2
- Page 26 and 27: Chapter 1 11piperazine) is also the
- Page 28 and 29: Chapter 1 13The four stereoisomers
- Page 30 and 31: Chapter 1 15single enantiomers and
- Page 32 and 33: Chapter 1 17was synthesized by the
- Page 34 and 35: Chapter 1 19HOHODesmolaseHOCholeste
- Page 36 and 37: Chapter 1 21formic acid results in
- Page 38 and 39: Chapter 1 23inactivation. 113 . Bec
- Page 40 and 41: Chapter 1 25Two newer compounds whi
- Page 42 and 43: Chapter 1 2715 is an advanced repre
- Page 44 and 45: Chapter 1 29transformation of the a
- Page 46 and 47: Chapter 1 31Enantioselective synthe
- Page 48 and 49: Chapter 1 33+R,S DRUG ANCHOR R MOLE
- Page 50 and 51: Chapter 1 35solubilized in hot etha
- Page 52 and 53: Chapter 2 37RsORmRmRsRLRL RRRLH - A
- Page 54 and 55: Chapter 2 39The stereochemistry and
- Page 56 and 57: Chapter 2 41An asymmetric reducing
- Page 58 and 59: Chapter 2 43This approach clearly e
- Page 60 and 61: Chapter 2 45PhaxeqP 1MP 2axeqPhP 2M
- Page 62 and 63: Chapter 2 47pyrrolidine ] 20 , LAH-
- Page 64 and 65: Chapter 2 49Enzymatic reactions are
- Page 66 and 67: Chapter 2 51As [ES] in equation 4 c
- Page 68 and 69: Chapter 2 53E+AK 1AK -1AEAK 2AE+PE+
- Page 70 and 71: Chapter 2 552.2.4 Lipases.Most lipa
- Page 72 and 73:
Chapter 2 57enzyme intermediate can
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Chapter 2 59projecting above the pl
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Chapter 2 612.3.1.1. Step 1: Adduct
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Chapter 2 63A -+ ROHRO - + AH'RO 2
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Chapter 2 65There are various effec
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Chapter 2 67The reactions were foun
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Chapter 2 69Yamanaka and coworkers
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Chapter 2 71sodium or potassium car
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Chapter 3 73The reaction is quite s
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Chapter 3 75literature as the best
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Chapter 3 77dry solvents and, is ch
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Chapter 3 79XXOH+ H 2 NDry K 2 CO 3
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Chapter 3 81substituents are the mo
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Chapter 3 83induces a rotation of t
- Page 100 and 101:
Chapter 3 85very sharp and it was p
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Chapter 3 87Raney NickelOH Br MeOH;
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Chapter 4 8933a-m were hydrolysed t
- Page 106 and 107:
Chapter 4 91benzo[b]furane (entries
- Page 108 and 109:
Chapter 4 93hydroxy or amine groups
- Page 110 and 111:
Chapter 4 95the products with ethyl
- Page 112 and 113:
Chapter 4 97NCO 2 HNCO 2 H(±)34c(-
- Page 114 and 115:
Chapter 4 99NNH37CO2EtOH(±)-27a(+)
- Page 116 and 117:
Chapter 4 101As already outlined ab
- Page 118 and 119:
Chapter 4 103(+)-(S)-2-octylimidazo
- Page 120 and 121:
Chapter 4 105CNNH N2 NCN nC 6 H 13N
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Chapter 4 107key step is the conver
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Chapter 4 109reverse addition in th
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Chapter 4 111which was eliminated e
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Chapter 4 113separate (±)-57a and
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Chapter 5 115to avoid this side rea
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Chapter 5 117Complete degradation o
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Chapter 5 119Entry R T °C Product
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Chapter 5 1212:1:3 in weight. All t
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Chapter 5 123reaction conditions we
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Chapter 5 125Entry Substrate R Time
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Chapter 5 127experiments. But it wa
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Chapter 5 129OClOSAM IIPH=7; R.T.OH
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Chapter 5 131OHOXHOHRHK 2 CO 3 ; Me
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Chapter 6 133HCuSO 4 .5H 2 O,NH 4 O
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Chapter 6 1356.2.1 Heteroannullatio
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Chapter 6 137This discovery allowed
- Page 154 and 155:
Chapter 6 139OH(±)-62OHFigure 6.1
- Page 156 and 157:
Chapter 6 141Entry Substrate R Time
- Page 158 and 159:
Chapter 6 143HOH58-a-c,e,h-lRPdCl 2
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Chapter 6 145afforded the benzo[b]f
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Chapter 6 147RR[P(Ph) 3 ]Pd°OHOPh
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Chapter 6 149H2-IodophenolOHOH(±)-
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Chapter 6 151presence of base as de
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Chapter 7 153A chiral lithium alumi
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Chapter 7 155derivatives were tried
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Chapter 7 157Finally an hypothesis
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Chapter 8 159were washed with a sat
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Chapter 8 16145 min, the mixture wa
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Chapter 8 1638.9 Decarboxylation of
- Page 180 and 181:
Chapter 8 165Alcohol 27a (0.2 mmol)
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Chapter 8 167for 48 h. After coolin
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Chapter 8 169room temperature for t
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Chapter 8 171in CH 2 Cl 2 and washe
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Chapter 8 1738.26 Screening of lipa
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Chapter 8 175Na 2 SO 4 . After remo
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Chapter 8 177NMR and MS analysis we
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Chapter 8 179Argon was bubbled thru
- Page 196 and 197:
Chapter 8 181IR (CHCl 3 ): ν cm-1=
- Page 198 and 199:
Chapter 8 183GC-MS: 305 M + (68%),
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Chapter 8 185[α] 20 D -5.7 (c 1.75
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Chapter 8 187Synthetic method 7.7.1
- Page 204 and 205:
Chapter 8 189(R,S)-(±)-1-(2-Octyl)
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Chapter 8 191M.P. = oil.Elementary
- Page 208 and 209:
Chapter 8 193Synthetic method 7.11.
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Chapter 8 195(±)-N-1-(2-Octyl)-2-t
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Chapter 8 197IR (CHCl 3 ) ν cm-1 =
- Page 214 and 215:
Chapter 8 199(±)-1-(4-Fluorophenyl
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Chapter 8 201Physical and spectral
- Page 218 and 219:
Chapter 8 203(±)-1-(Phenyl)-2-prop
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Chapter 8 205128.61, 128.87, 130.39
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Chapter 8 207min.Physical and spect
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Chapter 8 20913C J MOD NMR (CDCl 3
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Chapter 8 211(±)-2'-Methylphenyl-2
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Chapter 9 213References chapter 1:1
- Page 230 and 231:
Chapter 9 21531) De Felice, R.; Joh
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Chapter 9 21768) Brodie, A.M.H. in
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Chapter 9 219112) Brodie, A. M. H.;
- Page 236 and 237:
Chapter 9 2214) Karabatsos, M.C. J.
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Chapter 9 22334c) Blow D. Nature 19
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Chapter 9 22567a) Kundu, N.G.; Pal,
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Chapter 9 22712) Thompson,A.S.; Hum