- Page 1 and 2: Advances in the stereoselectivesynt
- Page 3: ACKNOWLEDGMENT:I would like to than
- Page 7 and 8: IndexIIndex:Chapter 1:1. Introducti
- Page 9 and 10: IndexIII3.2. Synthesis of Aryl-2-Be
- Page 11 and 12: IndexV5.3.4 Enzymatic hydrolysis of
- Page 13 and 14: IndexVII8.10.2 Synthesis of ethyl 4
- Page 15 and 16: IndexIX8.32 Synthesis of racemic 1-
- Page 17 and 18: Chapter 1 2Natural products13Chiral
- Page 19 and 20: Chapter 1 4trends have developed an
- Page 21 and 22: Chapter 1 6agents, antihystaminica,
- Page 23 and 24: Chapter 1 8HO2Figure 1.7: Ergostero
- Page 25 and 26: Chapter 1 10structure of the agent
- Page 27 and 28: Chapter 1 12Ketoconazole 4a is that
- Page 29 and 30: Chapter 1 14ClClORNClN5 a-dCl5aR=Cl
- Page 31 and 32: Chapter 1 16R'RNN6 a-d6 aR =R' = H6
- Page 33 and 34: Chapter 1 18In the last few years,
- Page 35 and 36: Chapter 1 20tool for controlling pa
- Page 37 and 38: Chapter 1 22describing the aromatiz
- Page 39 and 40: Chapter 1 24kinetics 112 . This ina
- Page 41 and 42: Chapter 1 26(NCS) producing drowsin
- Page 43 and 44: Chapter 1 28NCCNNN16NFigure 1.17: C
- Page 45 and 46: Chapter 1 30In vivo tests of compou
- Page 47 and 48: Chapter 1 32These apparently simila
- Page 49 and 50: Chapter 1 34RR'NS N2NConstruction o
- Page 51 and 52: Chapter 2 362. Theoretical Discussi
- Page 53 and 54: Chapter 2 38eclipsing the carbonyl
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Chapter 2 40The dramatically enhanc
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Chapter 2 42Brown's DIP-Chloride 21
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Chapter 2 44Chiral phosphine comple
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Chapter 2 46LiOHOHLiAlH 4EtOHOOHAlO
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Chapter 2 48LAH 1,5 (OR) 2,5dry Eth
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Chapter 2 50saturation effect is a
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Chapter 2 52This equation can be fu
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Chapter 2 54This analysis shows tha
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Chapter 2 56The generally accepted
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Chapter 2 58three different enzymes
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Chapter 2 60Another example is the
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Chapter 2 62Three different factors
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Chapter 2 642.3.1.2.2. Effect of Su
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Chapter 2 66XYH+RR'MYRR'X= Br, IY=
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Chapter 2 68IHCu 2OOHRPy, reflux,N
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Chapter 2 70R 1AXR 2 H R 3OH+A = N,
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Chapter 3 723. Synthesis of Substra
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Chapter 3 74R'ROCl+R'AlCl 3ROA a-f2
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Chapter 3 76NCBr 2 ; CH 2 Cl 2NCBrO
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Chapter 3 78Product R R' T °C Yiel
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Chapter 3 80ether at 0°C, under an
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Chapter 3 82Product X R Yield % e.e
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Chapter 3 84leading to a distortion
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Chapter 3 863.5 Dehalogenation of a
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Chapter 4 884. Stereospecific Synth
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Chapter 4 90Entry Substrate Config.
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Chapter 4 92was 1:1, TLC analysis s
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Chapter 4 94The first measurements
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Chapter 4 96material. The third met
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Chapter 4 98HNO 3 and NaNO 2 at 0°
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Chapter 4 100indicated that the car
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Chapter 4 102LiOH 10%NNCO 2 EtEtOH
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Chapter 4 104nC 6 H 13NH 2H 2 NCNCN
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Chapter 4 106RNH 2Br OMeOMeK 2 CO 3
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Chapter 4 1084.5.2. Direct conversi
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Chapter 4 110R R 1N 3OH27a,c,g,mDPP
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Chapter 4 112enantiopure azides. It
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Chapter 5 1145. Synthesis of Aryl p
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Chapter 5 116product resulting from
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Chapter 5 118MeOOMeMeOSiMe 3K 2 CO
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Chapter 5 120fluorescens (SAM II).
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Chapter 5 122other batches were che
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Chapter 5 124converted into alcohol
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Chapter 5 126Three different solven
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Chapter 5 1285.4 Synthesis of the r
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Chapter 5 1302) the hydrolysis of a
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Chapter 6 1326 Synthesis of Aryl-2-
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Chapter 6 1341-Phenyl-2-propyl-1-ol
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Chapter 6 136Table 6.1), tributylam
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Chapter 6 1386.2.4. Optimization of
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Chapter 6 1406.3 Cyclization of rac
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Chapter 6 142in the previous paragr
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Chapter 6 144corresponding prochira
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Chapter 6 146[P(Ph) 3 PdCl 2 ]CuDIP
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Chapter 6 1481-phenyl-2-propyn-1-ol
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Chapter 6 150between aryliodide and
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Chapter 7 1527 Summary:Numerous dru
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Chapter 7 154the Mitsunobu reaction
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Chapter 7 156In order to obtain the
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Chapter 8 1588. Synthetic Procedure
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Chapter 8 160mixture as solid in sm
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Chapter 8 162(±)-27i was almost un
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Chapter 8 164aqueous phase which wa
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Chapter 8 1668.14 Synthesis of 5-am
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Chapter 8 168and the stirring was c
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Chapter 8 1708.23.2 Synthesis of 1-
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Chapter 8 172In 10 ml of MTBE 100 m
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Chapter 8 174carried out in a therm
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Chapter 8 176solution and finally d
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Chapter 8 178addition of N-Mesyl-2-
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Chapter 8 180IR (CHCl 3 ): ν (cm-1
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Chapter 8 182Physical and spectral
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Chapter 8 184(±)-2',4'-Dichlorophe
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Chapter 8 186(R,S)-(±)-1-(2-Octyl)
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Chapter 8 1881H-NMR (200 MHz, CDCl
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Chapter 8 190Recrystallized from Et
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Chapter 8 192Elementary Analysis. c
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Chapter 8 194IR (CHCl 3 ) ν cm-1 =
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Chapter 8 196(S)-(+)-1-Phenyl-1-eth
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Chapter 8 19857c:Synthetic method 7
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Chapter 8 200Synthetic method 7.23.
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Chapter 8 202(±)-1-(4-Fluorophenyl
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Chapter 8 204the racemate (±)-61 b
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Chapter 8 206Physical and spectral
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Chapter 8 208(R)-(+)-3'-Fluoropheny
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Chapter 8 210(R)-(-)-4'-Fluoropheny
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Chapter 8 2121H NMR (CDCl 3 ) δ =
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Chapter 9 21415) Gibboson, G. F.; P
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Chapter 9 21648) Gip, L. and Forsst
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Chapter 9 21889) Brodie, A.M.H.; In
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Chapter 9 220Clinical use of Aromat
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Chapter 9 22218d) Cohen,N.; Loprest
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Chapter 9 22451) Mitsunobu, O.; Yam
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Chapter 9 22626) Brown, E.; Lézé,